The intravenous administration of 99m-technetium liposomes to healthy adult horses

Underwood, Claire, van Eps, Andrew W., Ross, Michael W., van Bloois, Louis, Storm, Gert, Van Tomme, Sophie R., Laverman, Peter and Schaer, Thomas P. (2009). The intravenous administration of 99m-technetium liposomes to healthy adult horses. In: Scientific Presentation Abstracts: 2009 ACVS Veterinary Symposium. 2009 ACVS Veterinary Symposium: The Surgical Summit, Washington, DC, U.S.A., (E48-E48). 8-10 October 2009. doi:10.1111/j.1532-950X.2009.00568.x

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Author Underwood, Claire
van Eps, Andrew W.
Ross, Michael W.
van Bloois, Louis
Storm, Gert
Van Tomme, Sophie R.
Laverman, Peter
Schaer, Thomas P.
Title of paper The intravenous administration of 99m-technetium liposomes to healthy adult horses
Conference name 2009 ACVS Veterinary Symposium: The Surgical Summit
Conference location Washington, DC, U.S.A.
Conference dates 8-10 October 2009
Convener American College of Veterinary Surgeons (ACVS)
Proceedings title Scientific Presentation Abstracts: 2009 ACVS Veterinary Symposium   Check publisher's open access policy
Journal name Veterinary Surgery   Check publisher's open access policy
Place of Publication Hoboken, NJ, U.S.A.
Publisher Wiley-Blackwell Publishing
Publication Year 2009
Sub-type Published abstract
DOI 10.1111/j.1532-950X.2009.00568.x
Open Access Status File (Author Post-print)
ISSN 0161-3499
1532-950X
Volume 38
Issue 6
Start page E48
End page E48
Total pages 1
Language eng
Formatted Abstract/Summary
Osteomyelitis is an infective process characterized by chronic morbidity. The persistence of this disease despite antimicrobial therapy may be attributed to poor tissue concentration, impaired local immune response, biofilm formation, changes in rate of bacterial growth and their quorum sensing abilities, and intracellular localization of pathogens. Therefore, the development of a new strategy for targeting antimicrobial agents to bone tissues is urgent. Liposomes have been extensively used as carriers of antimicrobial and antineoplastic drugs. Liposomes are phospholipid nanoparticles that extravasate at sites of increased vascular permeability, such as sites of infection. Liposomal encapsulation of antimicrobials is a drug delivery system that increases the therapeutic index of these drugs by increasing their concentration at the site of infection and reducing potential negative side effects. This study is the first to describe the intravenous administration of 99mTc-labelled polyethylene-glycol PEG) coated liposomes in horses. There were minimal adverse effects associated with intravenous administration of 99mTc labeled liposomes in healthy adult horses. This study establishes normal scintigraphic findings after administration of 99mTc PEG liposomes to which clinical images can be compared, with the goal of utilizing 99mTc-PEG liposomes as a diagnostic aid. Liposomes have significant potential in horses, as a diagnostic tool and for targeted drug delivery in the management of refractory infections and neoplasia. Having addressed safety issues associated with intravenous liposome administration in horses, we now plan to study distribution patterns and efficacy of intravenous liposome administration for targeted delivery of drugs in the treatment of refractory orthopedic and soft tissue infections.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Publication date: August 2009. Presented during the Stream Large Animal", during the Session "Equine Surgical Infections".

Document type: Conference Paper
Collection: School of Veterinary Science Publications
 
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Created: Mon, 07 Mar 2011, 14:41:54 EST by Dr Andrew Van Eps on behalf of School of Veterinary Science