An evaluation of inactivated infectious coryza vaccines containing a double-emulsion adjuvant system

Blackall, P.J., Eaves, L.E., Rogers, D.G. and Firth, G. (1992) An evaluation of inactivated infectious coryza vaccines containing a double-emulsion adjuvant system. Avian Diseases, 36 3: 632-636.


Author Blackall, P.J.
Eaves, L.E.
Rogers, D.G.
Firth, G.
Title An evaluation of inactivated infectious coryza vaccines containing a double-emulsion adjuvant system
Journal name Avian Diseases
Publication date 1992-07
Sub-type Article
DOI 10.2307/1591758
Volume number 36
Issue number 3
ISSN 0005-2086;1938-4351
Start page 632
End page 636
Total pages 5
Place of publication Jacksonville, FL, United States
Publisher American Association of Avian Pathologists
Language eng
Abstract The efficacy of experimental inactivated infectious coryza vaccines produced by a commercial vaccine manufacturer was evaluated. The vaccines, containing as the adjuvant phase either a double-emulsion mineral oil system or aluminum-hydroxide gel, were administered to 6-week-old chickens as a single dose. Some vaccines were a monovalent product containing a Page serovar C Haemophilus paragallinarum strain, and others were a bivalent product containing both Page serovar A and serovar C strains. After 3 weeks, all chickens were challenged by infraorbital sinus inoculation of virulent H. paragallinarum, either Page serovar C (strain HP31) or Page serovar A (strain HP14). The monovalent serovar C double-emulsion-based vaccines gave significant protection against a serovar C challenge, with the level of protection varying from 60% to 100%. The monovalent serovar C aluminum-hydroxide-gel vaccine also gave significant protection (94%) against a serovar C challenge. The bivalent double-emulsion vaccine gave significant protection against challenge from both serovars (100% for serovar C and 83% for serovar A). Although no major adverse reactions were detected, some chickens receiving both the double-emulsion vaccines and the aluminum-hydroxide vaccine developed relatively minor granulomatous reactions at the site of injection.
Keyword Hemophilus paragallinarum
Efficacy
Antigen
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article
Collection: Queensland Alliance for Agriculture and Food Innovation
 
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