Dynamics of the "Popcorn" Wolbachia infection in outbred Aedes aegypti informs prospects for mosquito vector control

Yeap, H. L., Mee, P., Walker, T., Weeks, A. R., O'Neill, S. L., Johnson, P., Ritchie, S. A., Richardson, K. M., Doig, C., Endersby, N. M. and Hoffmann, A. A. (2011) Dynamics of the "Popcorn" Wolbachia infection in outbred Aedes aegypti informs prospects for mosquito vector control. Genetics, 187 2: 583-U346. doi:10.1534/genetics.110.122390

Author Yeap, H. L.
Mee, P.
Walker, T.
Weeks, A. R.
O'Neill, S. L.
Johnson, P.
Ritchie, S. A.
Richardson, K. M.
Doig, C.
Endersby, N. M.
Hoffmann, A. A.
Title Dynamics of the "Popcorn" Wolbachia infection in outbred Aedes aegypti informs prospects for mosquito vector control
Journal name Genetics   Check publisher's open access policy
ISSN 0016-6731
Publication date 2011-02
Sub-type Article (original research)
DOI 10.1534/genetics.110.122390
Volume 187
Issue 2
Start page 583
End page U346
Total pages 17
Place of publication Bethesda MD, United States
Publisher Genetics Society of America
Collection year 2012
Language eng
Abstract Forty percent of the world's population is at risk of contracting dengue virus, which produces dengue fever with a potentially fatal hemorrhagic form. The wMelPop Wolbachia infection of Drosophila melanogaster reduces life span and interferes with viral transmission when introduced into the mosquito Aedes aegypti, the primary vector of dengue virus. Wolbachia has been proposed as an agent for preventing transmission of dengue virus. Population invasion by Wolbachia depends on levels of cytoplasmic incompatibility, fitness effects, and maternal transmission. Here we characterized these traits in an outbred genetic background of a potential target population of Ae. aegypti using two crossing schemes. Cytoplasmic incompatibility was strong in this background, and the maternal transmission rate of Wolbachia was high. The infection substantially reduced longevity of infected adult females, regardless of whether adults came from larvae cultured under high or low levels of nutrition or density. The infection reduced the viability of diapausing and nondiapausing eggs. Viability was particularly low when eggs were laid by older females and when diapausing eggs had been stored for a few weeks. The infection affected mosquito larval development time and adult body size under different larval nutrition levels and densities. The results were used to assess the potential for wMelPop-CLA to invade natural populations of Ae. aegypti and to develop recommendations for the maintenance of fitness in infected mosquitoes that need to compete against field insects.
Keyword Life-shortening wolbachia
Cytoplasmic incompatibility
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biological Sciences Publications
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Created: Sun, 06 Mar 2011, 00:13:07 EST