Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: A magnetic resonance imaging study

Hoenig, Michael R., Cowin, Gart, Buckley, Raymond, McHenery, Christine and Coulthard, Allan (2011) Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: A magnetic resonance imaging study. Lipids in Health and Disease, 10 12: 12-1-12-6. doi:10.1186/1476-511X-10-12


Author Hoenig, Michael R.
Cowin, Gart
Buckley, Raymond
McHenery, Christine
Coulthard, Allan
Title Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: A magnetic resonance imaging study
Journal name Lipids in Health and Disease   Check publisher's open access policy
ISSN 1476-511X
Publication date 2011-01
Sub-type Article (original research)
DOI 10.1186/1476-511X-10-12
Open Access Status DOI
Volume 10
Issue 12
Start page 12-1
End page 12-6
Total pages 6
Place of publication London, U. K.
Publisher BioMed Central
Collection year 2012
Language eng
Formatted abstract
Background: Visceral Fat Area (VFA) is an independent predictor of coronary disease. While low density lipoprotein cholesterol (LDL-C) is used to determine risk and guide therapy, its accuracy fails in obese patients who may have low LDL-C despite high VFA.

Objective: We sought to describe the relationship between VFA, LDL-C and to describe shifting cholesterol metabolism with increasing VFA.

Methods: 42 High-risk vascular patients not on lipid-lowering therapy provided a fasting lipid profile and underwent magnetic resonance imaging (MRI) to quantify VFA and subcutaneous fat area (SFA) at the L4-L5 disc. Comparisons: 1. Correlation between VFA, SFA, LDL-C and the standard lipid panel 2. Correlation between VFA, SFA and markers of cholesterol synthesis (desmosterol, lathosterol) and cholesterol absorption (cholestanol, sitosterol).

Results
VFA was inversely correlated with LDL-C (r = -0.348) indicating potential discordance between cardiovascular risk and LDL-C. However, VFA was appropriately correlated with other markers of increased risk: r = -0.361 with HDL-C, r = 0.503 with VLDL-C, r = 0.499 with TG (all p < 0.05). VFA did not correlate significantly with non-HDL-C. VFA correlated positively with cholesterol synthesis markers (desmosterol, lathosterol) and negatively with an absorption marker (cholestanol).

Conclusions: LDL-C is inversely correlated with VFA and this may explain the loss of the relationship between LDL-C and cardiovascular events in the obese. While Non-HDL-C did not correlate positively with VFA, the absence of a negative correlation suggests that it may be a more appropriate lipid target in an increasingly obese world.
Keyword Cornoary-heart disease
Excess body-weight
Apolipoprotein-B
Metabolic syndrome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 12.

 
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Created: Sun, 06 Mar 2011, 00:07:29 EST