Control strategies for endemic childhood scabies

Gilmore, Stephen J. (2011) Control strategies for endemic childhood scabies. PLoS One, 6 1: 1-14. doi:10.1371/journal.pone.0015990


Author Gilmore, Stephen J.
Title Control strategies for endemic childhood scabies
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2011-01
Sub-type Article (original research)
DOI 10.1371/journal.pone.0015990
Open Access Status DOI
Volume 6
Issue 1
Start page 1
End page 14
Total pages 14
Place of publication San Francisco CA , United States
Publisher Public Library of Science
Collection year 2012
Language eng
Formatted abstract
Human scabies is a major global public health issue, with an estimated 300 million cases per year worldwide. Prevalence rates are particularly high in many third-world regions and within various indigenous communities in developed countries. Infestation with Sarcoptes Scabiei is associated with group-A streptococcal pyoderma which in turn predisposes to rheumatic fever, acute glomerulonephritis and their respective long-term sequelae: rheumatic heart disease and chronic renal insufficiency. The documented difficulties inherent in achieving scabies control within affected communities have motivated us to develop a network-dependent Monte-Carlo model of the scabies contagion, with the dual aims of gaining insight into its dynamics, and in determining the effects of various treatment strategies. Here we show that scabies burden is adversely affected by increases in average network degree, prominent network clustering, and by a person-to-person transmissibility of greater magnitude. We demonstrate that creating a community-specific model allows for the determination of an effective treatment protocol that can satisfy any pre-defined target prevalence. We find frequent low-density treatment protocols are inherently advantageous in comparison with infrequent mass screening and treatment regimes: prevalence rates are lower when compared with protocols that administer the same number of treatments over a given time interval less frequently, and frequent low-density treatment protocols have economic, practical and public acceptance advantages that may facilitate their long-term implementation. This work demonstrates the importance of stochasticity, community structure and the heterogeneity of individuals in influencing the dynamics of the human scabies contagion, and provides a practical method for investigating the outcomes of various intervention strategies.
Keyword Permethrin cream
Ivermectin
Community
Disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Sun, 06 Mar 2011, 00:03:23 EST