Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors

Hezmee, Mohd Noor Mohd, Kyaw-Tanner, Myat, Lee, Jia Yu Peppermint, Shiels, Ian A., Rolfe, Barbara, Woodruff, Trent and Mills, Paul C. (2011) Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors. Veterinary Immunology and Immunopathology, 139 1: 50-56. doi:10.1016/j.vetimm.2010.08.005

Author Hezmee, Mohd Noor Mohd
Kyaw-Tanner, Myat
Lee, Jia Yu Peppermint
Shiels, Ian A.
Rolfe, Barbara
Woodruff, Trent
Mills, Paul C.
Title Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors
Journal name Veterinary Immunology and Immunopathology   Check publisher's open access policy
ISSN 0165-2427
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.vetimm.2010.08.005
Volume 139
Issue 1
Start page 50
End page 56
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2011
Language eng
Formatted abstract
Mammary tumors are among the most common neoplastic conditions in dogs, and there is evidence that inflammation plays a role in the development of some tumor types in dogs. The complement system is a major participant in the inflammatory process and the complement activation component, C5a, is a potent inflammatory peptide. This study investigated the mRNA expression of the major receptor for C5a (C5aR; CD88) in histopathological samples of canine mammary tumors by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) using canine-specific primers for CD88. A total of seven canine mammary tumors (four malignant carcinomas, two benign mixed mammary tumors, and one myoepithelioma) and eight normal mammary glands were analysed. All the tumor samples expressed low levels of CD88 mRNA, while none of the normal mammary tissues showed any detectable expression. These preliminary results suggest that C5a–CD88 interaction may play a contributory role in the inflammatory response associated with mammary tumor development in dogs. Further studies investigating the mechanisms behind complement activation and C5a receptor expression in canine mammary tumors are warranted.
© 2010 Elsevier B.V. All rights reserved.
Keyword Canine mammary tumor
Complement factor C5a
Polymerase chain reaction (PCR)
C5a receptor
Human peripheral-blood
Anaphylatoxin receptor
Complement activation
Polymorphonuclear leukocytes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 17 August 2010. Note that Author Mohd Hezmee Mohd Noor's name seems to be incorrectly reproduced in this article.

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Created: Sun, 06 Mar 2011, 00:01:00 EST