Dynamic control of neuroexocytosis by phosphoinositides in health and disease

Wen, Peter, Osborne, Shona L. and Meunier, Frederic A. (2011) Dynamic control of neuroexocytosis by phosphoinositides in health and disease. Progress in Lipid Research, 50 1: 52-61. doi:10.1016/j.plipres.2010.08.001

Author Wen, Peter
Osborne, Shona L.
Meunier, Frederic A.
Title Dynamic control of neuroexocytosis by phosphoinositides in health and disease
Journal name Progress in Lipid Research   Check publisher's open access policy
ISSN 0163-7827
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.plipres.2010.08.001
Volume 50
Issue 1
Start page 52
End page 61
Total pages 10
Place of publication United Kingdom
Publisher Pergamon
Collection year 2011
Language eng
Abstract Phosphoinositides are a group of phospholipids whose inositol headgroups can be phosphorylated at three distinct positions thereby generating seven different isotypes. The conversion between these lipid species depends on the activity of specific sets of phosphoinositide kinases and phosphatases whose targeting and activity is critical to establish the landscape of phosphoinositides on the cytosol-facing hemi-membrane of all organelles and plasmalemma. Phosphoinositides play pleiotropic roles ranging from signalling and membrane trafficking to modulation of ion channels and survival. In neurons and neurosecretory cells, whose main function is to communicate through the release of neurotransmitter, most of the work has focused on the role played by phosphatidylinositol (4,5) bisphosphate in controlling the mechanism underpinning neurotransmitter release through the fusion of secretory vesicles with the plasmalemma. Emerging evidence supports a multi-faceted regulation of neuroexocytosis by 3-phosphorylated phosphoinositides. In this review, we summarise the molecular mechanism by which these lipids control exocytosis and how minute changes in their metabolism can have devastating effects in the nervous system and lead to neurodegeneration. © 2010 Elsevier Ltd. All rights reserved.
Keyword Actin
Neurodegenerative diseases
Phosphoinositides signalling
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 10 August 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 04 Mar 2011, 14:44:13 EST by Debra McMurtrie on behalf of Queensland Brain Institute