Methylphenidate but not atomoxetine or citalopram modulates inhibitory control and response time variability

Nandam, L. Sanjay, Hester, Robert, Wagner, Joe, Cummins, Tarrant D. R., Garner, Kelly, Dean, Angela J., Kim, Bung Nyun, Nathan, Pradeep J., Mattingley, Jason B. and Bellgrove, Mark A. (2011) Methylphenidate but not atomoxetine or citalopram modulates inhibitory control and response time variability. Biological Psychiatry, 69 9: 902-904. doi:10.1016/j.biopsych.2010.11.014


Author Nandam, L. Sanjay
Hester, Robert
Wagner, Joe
Cummins, Tarrant D. R.
Garner, Kelly
Dean, Angela J.
Kim, Bung Nyun
Nathan, Pradeep J.
Mattingley, Jason B.
Bellgrove, Mark A.
Title Methylphenidate but not atomoxetine or citalopram modulates inhibitory control and response time variability
Journal name Biological Psychiatry   Check publisher's open access policy
ISSN 0006-3223
1873-2402
Publication date 2011-05-11
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.biopsych.2010.11.014
Volume 69
Issue 9
Start page 902
End page 904
Total pages 3
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2011
Language eng
Formatted abstract
Background: Response inhibition is a prototypical executive function of considerable clinical relevance to psychiatry. Nevertheless, our understanding of its pharmacological modulation remains incomplete.
Methods: We used a randomized, double-blind, placebo-controlled, crossover design to examine the effect of an acute dose of methylphenidate (MPH) (30 mg), atomoxetine (ATM) (60 mg), citalopram (CIT) (30 mg), and placebo (PLAC) (dextrose) on the stop signal inhibition task in 24 healthy, right-handed men 18-35 years of age. Participants performed the task under each of the four drug conditions across four consecutive sessions.
Results: Methylphenidate led to a reduction in both response time variability and stop-signal reaction time (SSRT), indicating enhanced response inhibition compared with all other drug conditions. Crucially, the enhancement of response inhibition by MPH occurred without concomitant changes in overall response speed, arguing against a simple enhancement of processing speed. We found no significant differences between ATM and PLAC, CIT and PLAC, or ATM and CIT for either response time variability or SSRT.
Conclusions:
An acute dose of MPH but not ATM or CIT was able to improve SSRT and reduce response time variability in nonclinical participants. Improvements in response inhibition and response variability might underlie the reported clinical benefits of MPH in disorders such as attention-deficit/hyperactivity disorder. © 2011 Society of Biological Psychiatry.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
School of Psychology Publications
 
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Created: Fri, 04 Mar 2011, 01:24:28 EST by Debra McMurtrie on behalf of Queensland Brain Institute