Potential of St John's Wort for the treatment of depression: the economic perspective

Solomon, Daniela, Ford, Emily, Adams, Jon and Graves, Nicholas (2011) Potential of St John's Wort for the treatment of depression: the economic perspective. Australian and New Zealand Journal of Psychiatry, 45 2: 123-130. doi:10.3109/00048674.2010.526094

Author Solomon, Daniela
Ford, Emily
Adams, Jon
Graves, Nicholas
Title Potential of St John's Wort for the treatment of depression: the economic perspective
Journal name Australian and New Zealand Journal of Psychiatry   Check publisher's open access policy
ISSN 0004-8674
Publication date 2011-02
Sub-type Article (original research)
DOI 10.3109/00048674.2010.526094
Volume 45
Issue 2
Start page 123
End page 130
Total pages 8
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2012
Language eng
Abstract The burden of rising health care expenditures has created a demand for information regarding the clinical and economic outcomes associated with complementary and alternative medicines. Meta-analyses of randomized controlled trials have found Hypericum perforatum preparations to be superior to placebo and similarly effective as standard antidepressants in the acute treatment of mild to moderate depression. A clear advantage over antidepressants has been demonstrated in terms of the reduced frequency of adverse effects and lower treatment withdrawal rates, low rates of side effects and good compliance, key variables affecting the cost-effectiveness of a given form of therapy. The most important risk associated with use is potential interactions with other drugs, but this may be mitigated by using extracts with low hyperforin content. As the indirect costs of depression are greater than five times direct treatment costs, given the rising cost of pharmaceutical antidepressants, the comparatively low cost of Hypericum perforatum extract makes it worthy of consideration in the economic evaluation of mild to moderate depression treatments. © 2011 The Royal Australian and New Zealand College of Psychiatrists.
Keyword Depression
Economic evaluation
St John's wort
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 02 Mar 2011, 14:45:53 EST by Geraldine Fitzgerald on behalf of School of Public Health