A bastadin with potent and selective delta-opioid receptor binding affinity from the Australian sponge lanthella flabelliformis

Carroll, Anthony R., Kaiser, Sonya M., Davis, Rohan A., Moni, Roger W., Hooper, John N. A. and Quinn, Ronald J. (2010) A bastadin with potent and selective delta-opioid receptor binding affinity from the Australian sponge lanthella flabelliformis. Journal of Natural Products, 73 6: 1173-1176.


Author Carroll, Anthony R.
Kaiser, Sonya M.
Davis, Rohan A.
Moni, Roger W.
Hooper, John N. A.
Quinn, Ronald J.
Title A bastadin with potent and selective delta-opioid receptor binding affinity from the Australian sponge lanthella flabelliformis
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
Publication date 2010-06-25
Sub-type Article (original research)
DOI 10.1021/np100010z
Volume 73
Issue 6
Start page 1173
End page 1176
Total pages 4
Place of publication United States
Publisher American Chemical Society
Collection year 2011
Language eng
Abstract Three new bastadins, bastadin 25 (1), 15-O-sulfonatobastadin 11 (2), and bastadin 26 (3), were isolated from a MeOH extract of the Australian marine sponge Ianthella flabelliformis. Their structures were determined by interpretation of 1D and 2D NMR spectra and mass spectrometry. Bastadin 26 (3) showed potent affinity for the guinea pig delta-opioid receptors with a K-i value of 100 nM. The other two bastadins had a 100-fold lower affinity. The three compounds were also tested for their affinity to guinea pig mu- and kappa-opioid receptors and shown to have either no affinity or only very weak affinity toward both of these apioid receptors.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Published online 19 July, 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 02 Mar 2011, 13:57:21 EST by Susan Allen on behalf of Institute for Molecular Bioscience