Propranolol in the management of periorbital infantile haemangioma

Cheng, Jin Fong, Gole, Glen A. and Sullivan, Timothy J. (2010) Propranolol in the management of periorbital infantile haemangioma. Clinical and Experimental Ophthalmology, 38 6: 547-553. doi:10.1111/j.1442-9071.2010.02344.x

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Author Cheng, Jin Fong
Gole, Glen A.
Sullivan, Timothy J.
Title Propranolol in the management of periorbital infantile haemangioma
Journal name Clinical and Experimental Ophthalmology   Check publisher's open access policy
ISSN 1442-6404
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1111/j.1442-9071.2010.02344.x
Volume 38
Issue 6
Start page 547
End page 553
Total pages 7
Place of publication Richmond, Vic., Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2011
Language eng
Formatted abstract
Background: Infantile haemangiomas are the commonest tumours of the orbit in children. Treatment is usually expectant, unless they are visually threatening. Although steroids, other pharmacological and surgical treatment modalities have their place, there are risks involved. A previous case series reported the successful use of propranolol for infantile haemangioma. The safety and efficacy of propranolol in the treatment of periorbital haemangioma was reviewed in a serious of our patients.
Methods: We performed a retrospective review of patients seen by two ophthalmologists (TJS and GAG), collecting data on colour, size of lesion, duration of treatment and side-effects of treatment. Our main outcome measures were colour and size of infantile haemangioma before and after treatment, the change in astigmatism of our patients and the incidence of complications from propranolol.
Results: We reviewed 10 patients with infantile haemangioma. They were treated with propranolol oral syrup 2 mg/kg/day in divided doses for a mean duration of 32.8 (range 12-42) weeks. All our patients had a reduction in colour and size of the lesions. The mean lesion size decreased from 756.7 to 543.2 mm2 after treatment (P = 0.075). Five patients had significant astigmatism and 60% had successful reduction of astigmatism after treatment. None of our patients suffered significant side-effects of propranolol.
Conclusion: Propranolol appears to be a safe and effective treatment in the management of infantile haemangioma.
© 2010 The Authors. Journal compilation © 2010 Royal Australian and New Zealand College of Ophthalmologists.
Keyword Beta-blocker
Capillary haemangioma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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Created: Wed, 02 Mar 2011, 11:10:03 EST by Melanie Thomas on behalf of Surgery - Royal Brisbane and Women's Hospital