Equine laminitis model: Cryotherapy reduces the severity of lesions evaluated seven days after induction with oligofructose

van Eps, A. W. and Pollitt, C. C. (2009) Equine laminitis model: Cryotherapy reduces the severity of lesions evaluated seven days after induction with oligofructose. Equine Veterinary Journal, 41 8: 741-746. doi:10.2746/042516409X434116


Author van Eps, A. W.
Pollitt, C. C.
Title Equine laminitis model: Cryotherapy reduces the severity of lesions evaluated seven days after induction with oligofructose
Journal name Equine Veterinary Journal   Check publisher's open access policy
ISSN 0425-1644
2042-3306
Publication date 2009-11
Year available 2010
Sub-type Article (original research)
DOI 10.2746/042516409X434116
Volume 41
Issue 8
Start page 741
End page 746
Total pages 5
Place of publication Hoboken, NJ, United States
Publisher John Wiley and Sons
Collection year 2011
Language eng
Formatted abstract
Reasons for performing study: A previous preliminary study demonstrated the potential of distal limb cryotherapy (DLC) for preventing laminitis. Clinically, DLC must be effective for periods longer than 48 h and the preventive effect must extend beyond its discontinuation.
Objectives:
To evaluate the effect of DLC, applied during the developmental phase of induced laminitis, on the severity of clinical laminitis and lamellar histopathology 7 days after dosing.
Methods:
Eighteen normal Standardbred horses were divided into 3 groups of 6. Continuous cryotherapy was applied for 72 h to the distal limbs of the first group. The second and third groups were administered laminitis inducing doses of oligofructose and 72 h of cryotherapy applied (immediately after dosing) to the second group. After clinical assessment all horses were subjected to euthanasia 7 days after dosing and hoof lamellar tissues were harvested and analysed.
Results:
In the laminitis induced horses clinical lameness and laminitis histopathology was significantly reduced in horses that underwent 72 h of DLC compared with untreated controls. Cryotherapy alone produced no significant lameness or other ill effect.
Conclusions:
Continuous, medium- to long-term (72 h) cryotherapy applied to the distal limbs of horses safely and effectively ameliorates the clinical signs and pathology of acute laminitis.
Potential relevance: Pre-emptive distal limb cryotherapy is a practical method of ameliorating laminitis in ill horses at risk of developing the disease.
Keyword Horse
Laminitis
Histopathology
Cryotherapy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 5 JAN 2010 (Print 2009)

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Veterinary Science Publications
 
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Created: Tue, 01 Mar 2011, 18:34:48 EST by Professor Christopher Pollitt on behalf of School of Veterinary Science