Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis

Stockton, K. A., Mengersen, K., Paratz, J. D., Kandiah, D. and Bennell, K. L. (2011) Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporosis International, 22 3: 859-871. doi:10.1007/s00198-010-1407-y


Author Stockton, K. A.
Mengersen, K.
Paratz, J. D.
Kandiah, D.
Bennell, K. L.
Title Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis
Journal name Osteoporosis International   Check publisher's open access policy
ISSN 0937-941X
Publication date 2011
Year available 2010
Sub-type Article (original research)
DOI 10.1007/s00198-010-1407-y
Volume 22
Issue 3
Start page 859
End page 871
Total pages 13
Place of publication United Kingdom
Publisher Springer U K
Collection year 2011
Language eng
Formatted abstract
Summary:
This systematic review demonstrates that vitamin D supplementation does not have a significant effect on muscle strength in vitamin D replete adults. However, a limited number of studies demonstrate an increase in proximal muscle strength in adults with vitamin D deficiency.

Introduction:

The purpose of this study is to systematically review the evidence on the effect of vitamin D supplementation on muscle strength in adults.

Methods:
Acomprehensive systematic database search was performed. Inclusion criteria included randomised controlled trials (RCTs) involving adult human participants. All forms and doses of vitamin D supplementation with or without calcium supplementation were included compared with placebo or standard care. Outcome measures included evaluation of strength. Outcomes were compared by calculating standardised mean difference (SMD) and 95% confidence intervals.

Results:

Of 52 identified studies, 17 RCTs involving 5,072 participants met the inclusion criteria. Meta-analysis showed no significant effect of vitamin D supplementation on grip strength (SMD -0.02, 95%CI -0.15,0.11) or proximal lower limb strength (SMD 0.1, 95%CI -0.01,0.22) in adults with 25(OH)D levels >25 nmol/L. Pooled data from two studies in vitamin D deficient participants (25(OH)D <25 nmol/L) demonstrated a large effect of vitamin D supplementation on hip muscle strength (SMD 3.52, 95%CI 2.18, 4.85).

Conclusion:
Based on studies included in this systematic review, vitamin D supplementation does not have a significant effect on muscle strength in adults with baseline 25(OH)D >25 nmol/L. However, a limited number of studies demonstrate an increase in proximal muscle strength in adults with vitamin D deficiency. © 2010 International Osteoporosis Foundation and National Osteoporosis Foundation.
Keyword Muscle
Muscle fibre
Strength
Vitamin D
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Health and Rehabilitation Sciences Publications
School of Medicine Publications
 
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Created: Tue, 01 Mar 2011, 15:34:46 EST by Dr Jennifer Paratz on behalf of School of Health & Rehabilitation Sciences