Incomplete pregnancy and risk of ovarian cancer: Results from two Australian case–control studies and systematic review

Dick, Marie-Louise B., Siskind, Vic, Purdie, David M., Green, Adele C., Australian Cancer Study Group (Ovarian Group) and The Australian Ovarian Cancer Study Group (2009) Incomplete pregnancy and risk of ovarian cancer: Results from two Australian case–control studies and systematic review. Cancer Causes Control, 20 9: 1571-1585. doi:10.1007/s10552-009-9402-3


Author Dick, Marie-Louise B.
Siskind, Vic
Purdie, David M.
Green, Adele C.
Australian Cancer Study Group (Ovarian Group)
The Australian Ovarian Cancer Study Group
Title Incomplete pregnancy and risk of ovarian cancer: Results from two Australian case–control studies and systematic review
Journal name Cancer Causes Control   Check publisher's open access policy
ISSN 0957-5243
1573-7225
Publication date 2009-11
Sub-type Article (original research)
DOI 10.1007/s10552-009-9402-3
Volume 20
Issue 9
Start page 1571
End page 1585
Total pages 15
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Abstract Although full-term pregnancies reduce the risk of ovarian cancer, it has not been conclusively established whether incomplete pregnancies also influence risk. We investigated the relationship between a history of incomplete pregnancy and incident epithelial ovarian cancer among over 4,500 women who participated in two large Australian population-based case–control studies in 1990– 1993 and 2002–2005. They provided responses to detailed questions about their reproductive histories and other personal factors. Summary odds ratios (OR) and confidence intervals (CI) derived for each study using the same covariates were aggregated. We found no significant associations between the number of incomplete pregnancies and ovarian cancer, for parous (OR = 0.98, 95% CI: 0.89, 1.08) or nulliparous (OR = 1.06, 95% CI: 0.75, 1.48) women, nor for the number of spontaneous or induced abortions and ovarian cancer for parous women (OR = 0.95, 95% CI 0.82, 1.09; OR = 1.08, 95% CI: 0.86, 1.36) or nulliparous women (OR = 1.2, 95% CI: 0.6, 2.4; OR = 0.8, 95% CI: 0.47, 1.38), respectively. A systematic review of 37 previous studies of the topic confirmed our findings that a history of incomplete pregnancy does not influence a woman’s risk of epithelial ovarian cancer.
Keyword Abortion
Spontaneous
Ovarian neoplasms
Risk
Carcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Full membership of the Australian Ovarian Cancer Study Group is listed at http://www.aocstudy.org/; the Australian Cancer Study

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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