Degradable hydrogels for tissue engineering - Part II: Responses of fibroblasts and macrophages to linear PHEMA

Keen, Imelda, Chirila, Traian V., Barnard, Zeke, Zainuddin and Whittaker, Andrew K. (2010) Degradable hydrogels for tissue engineering - Part II: Responses of fibroblasts and macrophages to linear PHEMA. Journal of Biomimetics, Biomaterials, and Tissue Engineering, 8 1: 91-104. doi:10.4028/www.scientific.net/JBBTE.8.91

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Author Keen, Imelda
Chirila, Traian V.
Barnard, Zeke
Zainuddin
Whittaker, Andrew K.
Title Degradable hydrogels for tissue engineering - Part II: Responses of fibroblasts and macrophages to linear PHEMA
Journal name Journal of Biomimetics, Biomaterials, and Tissue Engineering   Check publisher's open access policy
ISSN 1662-1018
1662-100X
1662-8993
Publication date 2010-11-17
Sub-type Article (original research)
DOI 10.4028/www.scientific.net/JBBTE.8.91
Volume 8
Issue 1
Start page 91
End page 104
Total pages 14
Editor A. J. Ruys
Place of publication Stafa-Zurich, Switzerland
Publisher Trans Tech Publications
Collection year 2011
Language eng
Formatted abstract
A series of linear poly(2-hydroxyethyl methacrylate) (PHEMA) with defined molecular weights (MW) and narrow molecular distributions were synthesized by reversible additionfragmentation chain transfer (RAFT) polymerization using cumyl dithiobenzoate (CDB) as a chain transfer agent. Murine fibroblasts (3T3) were exposed to eluates from various PHEMA samples, washed or unwashed, and with or without dithioester end groups. After 72 hrs in cell culture, no cytotoxic response was elicited by the polymer samples devoid of dithioester end groups, and which also underwent a thorough washing regime. Specimens throughout the entire MW range were internalized by a macrophage (cell line Raw 264), suggesting that such polymers can be used as models for studying the biodegradation of PHEMA.
© (2010) Trans Tech Publications, Switzerland.
Keyword Cytotoxicity
Fibroblasts
Macrophage
PHEMA hydrogel
RAFT polymerization
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 01 Mar 2011, 13:30:15 EST by Mrs Jennifer Brown on behalf of Aust Institute for Bioengineering & Nanotechnology