Controlled release of ketorolac through nanocomposite films of hydrogel and LDH-nanoparticles

Xu, Zhi Ping, Cheng, Xiaoxi, Rasoul, Firas, Whittaker, Andrew K. and Lu, Gaoqing Max (2011) Controlled release of ketorolac through nanocomposite films of hydrogel and LDH-nanoparticles. Journal of Nanoparticle Research, 13 3: 1253-1264. doi:10.1007/s11051-010-0118-9

Author Xu, Zhi Ping
Cheng, Xiaoxi
Rasoul, Firas
Whittaker, Andrew K.
Lu, Gaoqing Max
Title Controlled release of ketorolac through nanocomposite films of hydrogel and LDH-nanoparticles
Journal name Journal of Nanoparticle Research   Check publisher's open access policy
ISSN 1388-0764
Publication date 2011-03
Year available 2010
Sub-type Article (original research)
DOI 10.1007/s11051-010-0118-9
Volume 13
Issue 3
Start page 1253
End page 1264
Total pages 12
Place of publication Dordrecht, The Netherlands
Publisher Kluwer Academic Pub.
Collection year 2011
Language eng
Formatted abstract
A novel nanocomposite film for sustained release of anionic ophthalmic drugs through a double-control process has been examined in this study. The film, made as a drug-loaded contact lens, consists principally of a polymer hydrogel of 2-hydroxyethyl methacrylate (HEMA), in whose matrix MgAl-layered double hydroxide (MgAl-LDH) nanoparticles intercalated with the anionic drug are well dispersed. Such nanocomposite films (hydrogel-LDH-drug) contained 0.6-0.8 mg of MgAl-LDH and 0.08-0.09 mg of the ophthalmic drug (ketorolac) in 1.0 g of hydrogel. MgAl-drug-LDH nanoparticles were prepared with the hydrodynamic particle size of 40-200 nm. TEM images show that these nanoparticles are evenly dispersed in the hydrogel matrix. In vitro release tests of hydrogel-LDH-drug in pH 7.4 PBS solution at 32 °C indicate a sustained release profile of the loaded drug for 1 week. The drug release undergoes a rapid initial burst and then a monotonically decreasing rate up to 168 h. The initial burst release is determined by the film thickness and the polymerization conditions, but the following release rate is very similar, with the effective diffusion coefficient being nearly constant (3.0 × 10-12 m2/s). The drug release from the films is mechanistically attributed to anionic exchange and the subsequent diffusion in the hydrogel matrix. © 2010 Springer Science+Business Media B.V.
Keyword Double-control release
Drug delivery
Layered double hydroxide nanoparticles
Nanocomposite contact lens
Sustained release
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Tue, 01 Mar 2011, 13:26:27 EST by Mrs Jennifer Brown on behalf of Aust Institute for Bioengineering & Nanotechnology