A study of the swelling and model protein release behaviours of radiation-formed poly(N-vinyl 2-pyrrolidone-co-acrylic acid) hydrogels

Wang, David, Hill, David J. T., Rasoul, Firas and Whittaker, Andrew K. (2011). A study of the swelling and model protein release behaviours of radiation-formed poly(N-vinyl 2-pyrrolidone-co-acrylic acid) hydrogels. In: , Radiation Modification of Polymers. 11th Pacific Polymer Conference, Cairns, QLD, Australia, (207-212). 6-11 December 2009.


Author Wang, David
Hill, David J. T.
Rasoul, Firas
Whittaker, Andrew K.
Title of paper A study of the swelling and model protein release behaviours of radiation-formed poly(N-vinyl 2-pyrrolidone-co-acrylic acid) hydrogels
Conference name 11th Pacific Polymer Conference
Conference location Cairns, QLD, Australia
Conference dates 6-11 December 2009
Proceedings title Radiation Modification of Polymers   Check publisher's open access policy
Journal name Radiation Physics and Chemistry   Check publisher's open access policy
Place of Publication Oxford, U.K.
Publisher Pergamon
Publication Year 2011
Year available 2010
Sub-type Fully published paper
DOI 10.1016/j.radphyschem.2010.07.034
ISSN 0969-806X
1879-0895
Volume 80
Issue 2
Start page 207
End page 212
Total pages 6
Collection year 2011
Language eng
Abstract/Summary Hydrogels were prepared from poly(acrylic acid-co-N-vinyl pyrrolidone), poly(AA-co-VP) and mixtures of poly(AA-co-VP) and poly(ethylene oxide), PEO, by gamma radiolysis of aqueous solutions of the AA and VP monomers containing ethylene glycol dimethacrylate, EGDMA, as crosslinker and PEO. The AA/VP composition range of the poly(AA-co-VP) was XAA 0.7–0.9. The swelling behaviours of the hydrogels from the dry state were investigated in water (pH 6.5) and 50 mM 4-(2-hydroxyethyl)piperazine-1-ethylsulfonic acid buffer, HEPES buffer, at pH 7.4 and 295 K. The effects of poly(AA-co-VP) composition, crosslinker mole fraction and the presence of PEO on the equilibrium swelling ratio for the gels was examined. The kinetics of the release of a model protein, horseradish peroxidase, HRP, from the hydrogels in water were also studied at 295 K. Copyright © 2010 Elsevier Ltd All rights reserved.
Keyword Hydrogel
Poly(AA-co-NVP)
PEO
Radiation
Protein release
Swelling study
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 30 July 2010.

 
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