Enhanced cholinergic transmission promotes recall in honeybees

Guez, D., Zhu, H., Zhang, S. W. and Srinivasan, M. V. (2010) Enhanced cholinergic transmission promotes recall in honeybees. Journal of Insect Physiology, 56 9: 1341-1348. doi:10.1016/j.jinsphys.2010.04.022

Author Guez, D.
Zhu, H.
Zhang, S. W.
Srinivasan, M. V.
Title Enhanced cholinergic transmission promotes recall in honeybees
Journal name Journal of Insect Physiology   Check publisher's open access policy
ISSN 0022-1910
Publication date 2010-09
Sub-type Article (original research)
DOI 10.1016/j.jinsphys.2010.04.022
Volume 56
Issue 9
Start page 1341
End page 1348
Total pages 8
Place of publication United Kingdom
Publisher Pergamon
Collection year 2011
Language eng
Abstract The involvement of the cholinergic system in learning and memory in honeybees has been well established using olfactory conditioning. We examined the effect of Methyl Parathion (MeP), an acetylcholinesterase inhibitor of the organo-phosphate family, on the learning and recall of visual and olfactory discrimination tasks in honeybees. One of our expectations was to observe the effects induced by both the nicotinic and muscarinic systems, as the blocking of acetylcholinesterase should induce an increase in the activity of both systems. We were also interested in knowing whether the type of tasks could influence the results. The visual tasks involved learning to discriminate the orientation of gratings in a Y-maze; the olfactory task involved learning to discriminate odours in a proboscis extension reflex (PER) paradigm. The results indicate that MeP treatment enhances recall of learned tasks in the visual and olfactory domains, but it does not affect the acquisition phase in either domain. Surprisingly, MeP treatment led to muscarinic-like effects but failed to mimic the nicotinic-like effects already described in relation to learning phases in honeybees. Implications for the role of cholinergic pathways in learning and memory and the nature of their involvement are discussed, and a hypothesis relating to the organisation of the cholinergic system and the relationship between the nicotinic and muscarinic systems in honeybees is proposed. The results are also discussed in terms of their ecotoxicological consequences. © 2010 Elsevier Ltd.
Keyword Anticholinesterase
Apis mellifera
Associative learning
Cholinergic system
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
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Created: Mon, 28 Feb 2011, 10:36:16 EST by Debra McMurtrie on behalf of Queensland Brain Institute