Overview and recent advances in neuropathology. Part 1: Central nervous system tumours

Robertson, Thomas, Koszyca, Barbara and Gonzales, Michael (2011) Overview and recent advances in neuropathology. Part 1: Central nervous system tumours. Pathology, 43 2: 88-92. doi:10.1097/PAT.0b013e3283426e86

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Author Robertson, Thomas
Koszyca, Barbara
Gonzales, Michael
Title Overview and recent advances in neuropathology. Part 1: Central nervous system tumours
Journal name Pathology   Check publisher's open access policy
ISSN 1465-3931
0031-3025
Publication date 2011-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/PAT.0b013e3283426e86
Volume 43
Issue 2
Start page 88
End page 92
Total pages 5
Place of publication Surrey, United Kingdom
Publisher Wolters Kluwer
Collection year 2012
Language eng
Abstract This review highlights the recent changes to the World Health Organization (WHO) 4th edition of the classification of central nervous system tumours. The mixed glial and neuronal tumour group continues to expand to encompass three new subtypes of glioneuronal tumours. The main diagnostic points differentiating these tumours are covered. Also covered is an update on issues relating to grading of astrocytic, oligodendroglial and pineal tumours and the recent molecular subtypes observed in medulloblastomas. The theme of molecular genetics is continued in the following section where the four subtypes in the molecular subclassification of glioblastoma; classical, mesenchymal, proneural and neural are outlined. The genetic profile of these subtypes is highlighted as is their varying biological responses to adjuvant therapies. The relationship between chromosome 1p and 19q deletions and treatment responsive oligodendrogliomas is discussed, as are the newer advances relating to silencing of the MGMT gene in astrocytomas and mutations in the IDH-1 gene in both astrocytomas and oligodendrogliomas. The final section in this article provides an update on the concept of glioma stem cells.
Keyword Brain cancer propagating cells
Central nervous system
Glial tumours
Glioblastoma
Glioma stem cells
Glioneuronal tumours
IDH-1 gene
Medulloblastoma
MGMT gene
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Medicine Publications
 
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Created: Sun, 27 Feb 2011, 00:03:38 EST