Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972

Thompson, Mary F., Totsika, Makrina, Schembri, Mark A., Mills, Paul C., Seton, Erica J. and Trott, Darren J. (2011) Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972. Veterinary Microbiology, 147 1-2: 205-208. doi:10.1016/j.vetmic.2010.06.007


Author Thompson, Mary F.
Totsika, Makrina
Schembri, Mark A.
Mills, Paul C.
Seton, Erica J.
Trott, Darren J.
Title Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972
Formatted title
Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972
Journal name Veterinary Microbiology   Check publisher's open access policy
ISSN 0378-1135
1873-2542
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.vetmic.2010.06.007
Volume 147
Issue 1-2
Start page 205
End page 208
Total pages 4
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
Establishment of asymptomatic bacteriuria (ABU) with Escherichia coli 83972 is a viable prophylactic alternative to antibiotic therapy for the prevention of recurrent bacterial urinary tract infection in humans. Approximately 2×108 viable E. coli 83972 cells were introduced into the bladder of six healthy female dogs via a sterile urinary catheter. The presence of pyuria, depression, stranguria, pollakiuria and haematuria was documented for 6 weeks and urinalysis and aerobic bacterial cultures were performed every 24-72h. Pyuria was present in all dogs on day 1 post-inoculation and 4/6 dogs (67%) had a positive urine culture on this day. Duration of colonization ranged from 0 to 10 days (median 4 days). Four dogs were re-inoculated on day 20. Duration of colonization following the second inoculation ranged from 1 to 3 days. No dog suffered pyrexia or appeared systemically unwell but all dogs initially exhibited mild pollakiuria and a small number displayed gross haematuria and/or stranguria. By day 3 of each trial all clinical signs had resolved. Persistent bacteriuria was not achieved in any dog but two dogs were colonized for 10 days following a single inoculation. Further research is required to determine whether establishment of ABU in dogs with recurrent urinary tract infection is a viable alternative to repeated doses of antimicrobial agents.
Keyword Urinary tract infection
Bacteriuria
Canine
Bacterial interference
Colonization
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 17 June 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
School of Veterinary Science Publications
 
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Created: Sun, 27 Feb 2011, 00:00:52 EST