Measuring serum antibody to human papillomavirus following infection or vaccination

Frazer, Ian H. (2010) Measuring serum antibody to human papillomavirus following infection or vaccination. Gynecologic Oncology, 118 1 Supplement 1: S8-S11. doi:10.1016/j.ygyno.2010.04.003

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Author Frazer, Ian H.
Title Measuring serum antibody to human papillomavirus following infection or vaccination
Journal name Gynecologic Oncology   Check publisher's open access policy
ISSN 0090-8258
1095-6859
Publication date 2010-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ygyno.2010.04.003
Open Access Status File (Author Post-print)
Volume 118
Issue 1 Supplement 1
Start page S8
End page S11
Total pages 4
Editor Margaret Stanley
Beth Y. Karlan
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2011
Language eng
Formatted abstract
The family of human papillomaviruses (HPVs) includes more than 130 genotypes, many of which infect the genital tract, and these can be classified as low risk or high risk for induction of genital neoplasia. Two prophylactic vaccines are currently available for the prevention of genital HPV infection: a quadrivalent (Gardasil®; Merck & Co. Inc) and a bivalent (Cervarix™; GlaxoSmithKline) vaccine. Protection against HPV infection and associated disease is observed for at least 6.4 years following immunization with the bivalent vaccine and for at least 8.5 years with the HPV 16 L1 virus-like particle of the quadrivalent vaccine. HPV vaccines induce robust immune memory, as evidenced by recall of responses after revaccination, suggesting that immunization will afford long-lasting protection. An immunological marker for ongoing protection from infection would provide information to help establish best-practice deployment of these vaccines. However, while HPV-specific antibody is likely the major mechanism of protection against HPV infection following immunization, available serological assays provide only a partial characterization of immune status, and no measured immune response has been shown to define immediate or future protection against HPV infection or associated disease. Future research efforts should therefore be directed towards correlating measures of virus-specific immune memory with continued protection against infection with the HPV types in the available vaccines, and towards determining the duration of cross-protection afforded by these vaccines against HPV types other than those incorporated in the vaccines.
Keyword Human papillomavirus
Immune marker
Immune memory
Cross-protection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special issue: "Mechanism of HPV infection and the implications for the understanding of HPV induced long term protection. This educational activity is supported by an educational grant from Merck & Co. Inc."

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
UQ Diamantina Institute - Open Access Collection
UQ Diamantina Institute Publications
 
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Created: Fri, 25 Feb 2011, 13:08:09 EST by Kylie Hengst on behalf of UQ Diamantina Institute