Novel supramolecular hydrogels as artificial vitreous substitutes

Lee-Wang, Hui Hui, Blakey, Idriss, Chirila, Traian V., Peng, Hui, Rasoul, Firas, Whittaker, Andrew K. and Dargaville, Bronwin L. (2010). Novel supramolecular hydrogels as artificial vitreous substitutes. In: Modern Trends in Polymer Science – EPF'09 –. 12th European-Polymer-Federation Congress, Graz, Austria, (229-232). July 12-17 2009. doi:10.1002/masy.201051032

Author Lee-Wang, Hui Hui
Blakey, Idriss
Chirila, Traian V.
Peng, Hui
Rasoul, Firas
Whittaker, Andrew K.
Dargaville, Bronwin L.
Title of paper Novel supramolecular hydrogels as artificial vitreous substitutes
Conference name 12th European-Polymer-Federation Congress
Conference location Graz, Austria
Conference dates July 12-17 2009
Proceedings title Modern Trends in Polymer Science – EPF'09 –   Check publisher's open access policy
Journal name Macromolecular Symposia   Check publisher's open access policy
Place of Publication F. Stelzer
Publisher E. Wiesbrock
Publication Year 2010
Sub-type Fully published paper
DOI 10.1002/masy.201051032
ISBN *****************
ISSN 1022-1360
Volume 296
Issue 1
Start page 229
End page 232
Total pages 4
Collection year 2011
Language eng
Formatted Abstract/Summary
The possibility of employing self-healing gels as potential artificial vitreous substitutes is being explored. Advancement of traditional synthetic hydrogels as vitreous substitutes is hindered by their fragmentation upon injection into the vitreous cavity leading ultimately to inflammation. Preliminary work involved developing first generation self-healing gels, using amphiphilic tri-block copolymers of poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol) (PPG-PEG-PPG) as the building block. Eight linear self-healing gels are synthesized by tethering an ureidopyrimidinone system to synthetically modified PPG-PEG-PPG via the formation of a bis-urea as a linker. The reversible nature of the hydrogen bonds permits alteration of their physical properties by changing the environment, yet retaining desirable characteristics. Despite low solubility in water, these polymers demonstrated associating behaviour under the investigated conditions, which is encouraging. Future generations of self-healing gels should involve the selection of a more hydrophilic core and/or star-like polymers to facilitate gel formation and strengthen the network. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keyword Amphiphilic
Hydrogen bonding
Tri-block copolymers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 24 Feb 2011, 16:41:00 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging