Peptide rope tricks

Rosengren, K. Johan and Craik, David J. (2010) Peptide rope tricks. Chimica Oggi, 28 6: 28-32.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Author Rosengren, K. Johan
Craik, David J.
Title Peptide rope tricks
Journal name Chimica Oggi   Check publisher's open access policy
ISSN 0392-839X
Publication date 2010-11
Sub-type Article (original research)
Volume 28
Issue 6
Start page 28
End page 32
Total pages 5
Place of publication Milan, Italy
Publisher Tekno Scienze
Collection year 2011
Language eng
Abstract Lariat or lasso peptides are a structurally unique family of ribosomally synthesized bioactive peptides produced by microbes. They range from 16 to 21 residues in size and are characterized by a post-translational modification in the form of a lactam bond between a conserved aspartic or glutamic acid and the peptide N-terminus, resulting in an 8 or 9 residue macrocycle, which is threaded by the C-terminal part of the peptide chain. This noose-like feature results in unique properties, including remarkable chemical and biological stability, suggesting that this bacterial rope trick may well provide an ideal new framework for the design of peptide based pharmaceuticals.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under: Peptides / Oligos

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 24 Feb 2011, 12:39:11 EST by Susan Allen on behalf of Institute for Molecular Bioscience