Lifestyle factors associated concurrently and prospectively with co-morbid cardiovascular disease in a population-based cohort of colorectal cancer survivors

Hawkes, Anna L., Lynch, Brigid M., Owen, Neville and Aitken, Joanne F. (2011) Lifestyle factors associated concurrently and prospectively with co-morbid cardiovascular disease in a population-based cohort of colorectal cancer survivors. European Journal of Cancer, 47 2: 267-276. doi:10.1016/j.ejca.2010.10.002


Author Hawkes, Anna L.
Lynch, Brigid M.
Owen, Neville
Aitken, Joanne F.
Title Lifestyle factors associated concurrently and prospectively with co-morbid cardiovascular disease in a population-based cohort of colorectal cancer survivors
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
1879-0852
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.ejca.2010.10.002
Volume 47
Issue 2
Start page 267
End page 276
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2011
Language eng
Formatted abstract
Aims: To assess self-reported lifetime prevalence of cardiovascular disease (CVD) among colorectal cancer survivors, and examine the cross-sectional and prospective associations of lifestyle factors with co-morbid CVD.
Methods:
Colorectal cancer survivors were recruited (n = 1966). Data were collected at approximately 5, 12, 24 and 36 months post-diagnosis. Cross-sectional findings included six CVD categories (hypercholesterolaemia, hypertension, diabetes, heart failure, kidney disease and ischaemic heart disease (IHD)) at 5 months post-diagnosis. Longitudinal outcomes included the probability of developing (de novo) co-morbid CVD by 36 months post-diagnosis. Lifestyle factors included body mass index, physical activity, television (TV) viewing, alcohol consumption and smoking.
Results:
Co-morbid CVD prevalence at 5 months post-diagnosis was 59%, and 16% of participants with no known CVD at the baseline reported de novo CVD by 36 months. Obesity at the baseline predicted de novo hypertension (odds ratio [OR] = 2.20, 95% confidence intervals [CI] = 1.09, 4.45) and de novo diabetes (OR = 6.55, 95% CI = 2.19, 19.53). Participants watching >4 h of TV/d at the baseline (compared with <2 h/d) were more likely to develop ischaemic heart disease by 36 months (OR = 5.51, 95% CI = 1.86, 16.34).
Conclusion:
Overweight colorectal cancer survivors were more likely to suffer from co-morbid CVD. Interventions focusing on weight management and other modifiable lifestyle factors may reduce functional decline and improve survival.
© 2010 Elsevier Ltd. All rights reserved.
Keyword Colorectal cancer
Co-morbid
Cardiovascular disease
Lifestyle factors
Chronic disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 10 November 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Public Health Publications
 
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Created: Tue, 22 Feb 2011, 15:34:20 EST by Geraldine Fitzgerald on behalf of School of Public Health