Imaging brain opioid receptors in alcohol and heroin dependence

Lingford-Hughes, A. R., Daglish, M., Brooks, D. J. and Nutt, D. J. (2005). Imaging brain opioid receptors in alcohol and heroin dependence. In: 18th ECNP Congress 2005, Amsterdam, Netherlands, (S331-S331). 22-26 October 2005. doi:10.1016/S0924-977X(05)80632-7

Author Lingford-Hughes, A. R.
Daglish, M.
Brooks, D. J.
Nutt, D. J.
Title of paper Imaging brain opioid receptors in alcohol and heroin dependence
Conference name 18th ECNP Congress 2005
Conference location Amsterdam, Netherlands
Conference dates 22-26 October 2005
Journal name European Neuropsychopharmacology   Check publisher's open access policy
Place of Publication Amsterdam, Netherlands
Publisher Elsevier
Publication Year 2005
Sub-type Published abstract
DOI 10.1016/S0924-977X(05)80632-7
ISSN 0924-977X
Volume 15
Start page S331
End page S331
Total pages 1
Language eng
Formatted Abstract/Summary
Brain opioid receptors are involved in the reinforcing effects
of both opioids and alcohol. A neuroimaging study previously
showed increased levels of the mu opioid receptor in cocaine
addiction that was related to craving in early abstinence [Zubieta et
al 1996]. We have therefore investigated whether early abstinence
in heroin or alcohol dependence is also associated with increased
opioid receptor availability and craving. Two patient groups were
recruited: 1) heroin dependent patients in early abstinence from
methadone; 2) alcohol dependent patients who had been detoxified
with chlordiazepoxide. All underwent an PET scan with
[11C]diprenorphine, a nonselective opioid receptor tracer, on a
brain dedicated ECAT 953b scanner. An arterial input function
corrected for radioactive metabolites was calculated. Spectral
analysis was used to generate a volume of distribution (VD)
map of [11C]diprenorphine reflecting opioid receptor availability.
In both the heroin and alcohol dependent groups, a significant
[p < 0.05] increase in global VD was seen compared to the control
group. In the alcohol dependent group, 4 subjects were rescanned
after ~3 months abstinence and in 3 subjects, a reduction in
global [11C]diprenorphine VD was seen and related to a change
in reported craving. These results suggest that early abstinence
from alcohol or heroin in dependence is associated with increased
availability of opioid receptors in the brain. These findings are
consistent with those reported in early abstinence from cocaine
and is further evidence for a generic role of the endogenous opioid
system in substance dependence.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
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Created: Tue, 22 Feb 2011, 10:46:28 EST