Pedunculopontine nucleus deep brain stimulation produces sustained improvement in primary progressive freezing of gait

Wilcox, Robert A., Cole, Michael H., Wong, David, Coyne, Terry, Silburn, Peter and Kerr, Graham (2011) Pedunculopontine nucleus deep brain stimulation produces sustained improvement in primary progressive freezing of gait. Journal of Neurology, Neurosurgery and Psychiatry, 82 11: 1256-1259. doi:10.1136/jnnp.2010.213462


Author Wilcox, Robert A.
Cole, Michael H.
Wong, David
Coyne, Terry
Silburn, Peter
Kerr, Graham
Title Pedunculopontine nucleus deep brain stimulation produces sustained improvement in primary progressive freezing of gait
Journal name Journal of Neurology, Neurosurgery and Psychiatry   Check publisher's open access policy
ISSN 1468-330X
0022-3050
Publication date 2011-11-01
Year available 2010
Sub-type Article (original research)
DOI 10.1136/jnnp.2010.213462
Volume 82
Issue 11
Start page 1256
End page 1259
Total pages 4
Place of publication London, United Kingdom
Publisher BMJ Group
Collection year 2011
Language eng
Formatted abstract
Objective To assess the efficacy of bilateral pedunculopontine nucleus (PPN) deep brain stimulation (DBS) as a treatment for primary progressive freezing of gait (PPFG).
Methods A patient with PPFG underwent bilateral PPN-DBS and was followed clinically for over 14 months.
Results
The PPFG patient exhibited a robust improvement in gait and posture following PPN-DBS. When PPN stimulation was deactivated, postural stability and gait skills declined to pre-DBS levels, and fluoro-2-deoxy-d-glucose positron emission tomography revealed hypoactive cerebellar and brainstem regions, which significantly normalised when PPN stimulation was reactivated.
Conclusions This case demonstrates that the advantages of PPN-DBS may not be limited to addressing freezing of gait (FOG) in idiopathic Parkinson's disease. The PPN may also be an effective DBS target to address other forms of central gait failure.
Copyright Article author (or their employer) 2010.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published Online First 22 October 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
 
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Created: Tue, 22 Feb 2011, 19:54:17 EST by Caroline Irle on behalf of UQ Centre for Clinical Research