Skin wound healing modulation by macrophages

Rodero, Mathieu P. and Khosrotehrani, Kiarash (2010) Skin wound healing modulation by macrophages. International Journal of Clinical and Experimental Pathology, 3 7: 643-653.

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Author Rodero, Mathieu P.
Khosrotehrani, Kiarash
Title Skin wound healing modulation by macrophages
Journal name International Journal of Clinical and Experimental Pathology   Check publisher's open access policy
ISSN 1936-2625
Publication date 2010
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 3
Issue 7
Start page 643
End page 653
Total pages 11
Place of publication Madison, WI, United States
Publisher E-Century Publishing Corporation
Collection year 2011
Language eng
Abstract Skin wound healing is a multi stage phenomenon that requires the activation, recruitment or activity of numerous cell types as keratinocytes, endothelial cells, fibroblast and inflammatory cells. Among the latter, macrophages appear to be central to this process. They colonize the wound at its very early stage and in addition to their protective immune role seem to organize the activity of other cell types at the following stages of the healing. Their benefit to this process is however controversial, as macrophages are described to promote the speed of healing but may also favour the fibrosis resulting from it in scars. Moreover wound healing defects are associated with abnormalities in the inflammatory phase. In this review, we summarise our knowledge on what are the Wound Associated Macrophages, and how they interact with the other cell types to control the reepithelialisation, angiogenesis and the extracellular matrix remodelling. We believe this knowledge may open new avenues for therapeutic intervention on skin wounds.
Keyword Macrophage
Skin wound
Healing
Inflammation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
 
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Created: Mon, 21 Feb 2011, 14:55:36 EST by Caroline Irle on behalf of UQ Centre for Clinical Research