Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa

Thurber, Rebecca L. Vega, Barott, Katie L., Hall, Dana, Liu, Hong, Rodriguez-Mueller, Beltran, Desnues, Christelle, Edwards, Robert A., Haynes, Matthew, Angly, Florent E., Wegley, Linda and Rohwer, Forest L. (2008) Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa. Proceedings of the National Academy of Sciences of the United States of America, 105 47: 18413-18418. doi:10.1073/pnas.0808985105


Author Thurber, Rebecca L. Vega
Barott, Katie L.
Hall, Dana
Liu, Hong
Rodriguez-Mueller, Beltran
Desnues, Christelle
Edwards, Robert A.
Haynes, Matthew
Angly, Florent E.
Wegley, Linda
Rohwer, Forest L.
Title Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa
Formatted title
Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2008-11-25
Sub-type Article (original research)
DOI 10.1073/pnas.0808985105
Open Access Status Not Open Access
Volume 105
Issue 47
Start page 18413
End page 18418
Total pages 6
Place of publication Washington, DC, United States
Publisher National Academy of Sciences
Language eng
Formatted abstract
During the last several decades corals have been in decline and at least one-third of all coral species are now threatened with extinction. Coral disease has been a major contributor to this threat, but little is known about the responsible pathogens. To date most research has focused on bacterial and fungal diseases; however, viruses may also be important for coral health. Using a combination of empirical viral metagenomics and real-time PCR, we show that Porites compressa corals contain a suite of eukaryotic viruses, many related to the Herpesviridae. This coral-associated viral consortium was found to shift in response to abiotic stressors. In particular, when exposed to reduced pH, elevated nutrients, and thermal stress, the abundance of herpes-like viral sequences rapidly increased in 2 separate experiments. Herpes-like viral sequences were rarely detected in apparently healthy corals, but were abundant in a majority of stressed samples. In addition, surveys of the Nematostella and Hydra genomic projects demonstrate that even distantly related Cnidarians contain numerous herpes-like viral genes, likely as a result of latent or endogenous viral infection. These data support the hypotheses that corals experience viral infections, which are exacerbated by stress, and that herpes-like viruses are common in Cnidarians.
Keyword Coral reefs
Disease
Herpesviridae
Viral-like particles
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Chemistry and Molecular Biosciences
 
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Created: Mon, 21 Feb 2011, 14:31:25 EST