Long-term intermittent multiple micronutrient supplementation enhances hemoglobin and micronutrient status more than iron + folic acid supplementation in Bangladeshi rural adolescent girls with nutritional anemia

Ahmed, Faruk, Khan, Moududur R., Akhtaruzzaman, Mohammad, Karim, Rezau, Williams, Gail, Torlesse, Harriet, Darnton-Hill, Ian, Dalmiya, Nita, Banu, Cadi P. and Nahar, Badrun (2010) Long-term intermittent multiple micronutrient supplementation enhances hemoglobin and micronutrient status more than iron + folic acid supplementation in Bangladeshi rural adolescent girls with nutritional anemia. Journal of Nutrition, 140 10: 1879-1886. doi:10.3945/jn.109.119123


Author Ahmed, Faruk
Khan, Moududur R.
Akhtaruzzaman, Mohammad
Karim, Rezau
Williams, Gail
Torlesse, Harriet
Darnton-Hill, Ian
Dalmiya, Nita
Banu, Cadi P.
Nahar, Badrun
Title Long-term intermittent multiple micronutrient supplementation enhances hemoglobin and micronutrient status more than iron + folic acid supplementation in Bangladeshi rural adolescent girls with nutritional anemia
Journal name Journal of Nutrition   Check publisher's open access policy
ISSN 0022-3166
1541-6100
Publication date 2010-10-01
Sub-type Article (original research)
DOI 10.3945/jn.109.119123
Volume 140
Issue 10
Start page 1879
End page 1886
Total pages 8
Editor A. Catherine Ross
Place of publication Bethesda, MD, United States
Publisher American Society for Nutrition
Collection year 2011
Language eng
Formatted abstract
Previous short-term supplementation studies showed no additional hematologic benefit of multiple micronutrients (MMN) compared with iron + folic acid (IFA) in adolescent girls. This study examines whether long-term once- or twice-weekly supplementation of MMN can improve hemoglobin (Hb) and micronutrient status more than twice-weekly IFA supplementation in anemic adolescent girls in Bangladesh. Anemic girls (n = 324) aged 11-17 y attending rural schools were given once- or twice-weekly MMN or twice-weekly IFA, containing 60 mg iron/dose in both supplements, for 52 wk in a randomized double-blind trial. Blood samples were collected at baseline and 26 and 52 wk. Intent to treat analysis showed no significant difference in the Hb concentration between treatments at either 26 or 52 wk. However, after excluding girls with hemoglobinopathy and adjustment for baseline Hb, a greater increase in Hb was observed with twice-weekly MMN at 26 wk (P = 0.045). Although all 3 treatments effectively reduced iron deficiency, once-weekly MMN produced significantly lower serum ferritin concentrations than the other treatments at both 26 and 52 wk. Both once- and twice-weekly MMN significantly improved riboflavin, vitamin A, and vitamin C status compared with IFA. Overall, once-weekly MMN was less efficacious than twice-weekly MMN in improving iron, riboflavin, RBC folic acid, and vitamin A levels. Micronutrient supplementation beyond 26 wk was likely important in sustaining improved micronutrient status. These findings highlight the potential usefulness of MMN intervention in this population and have implications for programming.
© 2010 American Society for Nutrition.
Keyword Ferritin
Pregnancy
Children
Women
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Supplemental Figure 1 is available with the online posting of this paper at nutrition.org.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Public Health Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 20 Feb 2011, 00:03:21 EST