Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer

Edgell, Tracey A., Barraclough, Dong L., Rajic, Antonio, Dhulia, Janu, Lewis, Kate J., Armes, Jane E.., Barraclough, Roger, Rudland, Philip S., Rice, Gregory E. and Autelitano, Dominic J. (2010) Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer. Clinical Science, 118 12: 717-725. doi:10.1042/CS20090537


Author Edgell, Tracey A.
Barraclough, Dong L.
Rajic, Antonio
Dhulia, Janu
Lewis, Kate J.
Armes, Jane E..
Barraclough, Roger
Rudland, Philip S.
Rice, Gregory E.
Autelitano, Dominic J.
Title Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer
Journal name Clinical Science   Check publisher's open access policy
ISSN 0143-5221
1470-8736
Publication date 2010-06
Sub-type Article (original research)
DOI 10.1042/CS20090537
Volume 118
Issue 12
Start page 717
End page 725
Total pages 9
Place of publication London, United Kingdom
Publisher Portland Press
Collection year 2011
Language eng
Formatted abstract
Ovarian cancer is often asymptomatic and is diagnosed at an advanced stage with poor survival rates, thus there is an urgent need to develop biomarkers for earlier detection of ovarian cancer. In the present study, we demonstrate for the first time that the previously reported metastasis-inducing protein AGR2 (anterior gradient protein 2) can be detected in the blood of ovarian cancer patients. Using a newly developed ELISA, we show significantly increased concentrations of AGR2 protein in plasma from cancer patients relative to normal controls. Plasma AGR2 concentrations were highest in stages II and III ovarian cancer patients and were similarly elevated in patients with both serous and non-serous tumours. The identification of elevated plasma concentrations of AGR2 may provide a useful biomarker to aid in the discrimination of normal and ovarian cancer patients particularly when used in combination with CA125. © The Authors.
Keyword Anterior gradient protein 2 (AGR2)
Biomarker
CA125
Ovarian cancer
Elisa
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Non HERDC
 
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 18 Feb 2011, 11:26:33 EST by Caroline Irle on behalf of Medicine - Mater Hospital