Mortality among cocaine users: A systematic review of cohort studies

Degenhardt, Louisa, Singleton, Jessica, Calabria, Bianca, McLaren, Jennifer, Kerr, Thomas, Mehta, Shruti, Kirk, Gregory and Hall, Wayne D. (2011) Mortality among cocaine users: A systematic review of cohort studies. Drug And Alcohol Dependence, 113 2-3: 88-95. doi:10.1016/j.drugalcdep.2010.07.026

Author Degenhardt, Louisa
Singleton, Jessica
Calabria, Bianca
McLaren, Jennifer
Kerr, Thomas
Mehta, Shruti
Kirk, Gregory
Hall, Wayne D.
Title Mortality among cocaine users: A systematic review of cohort studies
Journal name Drug And Alcohol Dependence   Check publisher's open access policy
ISSN 0376-8716
Publication date 2011-01-15
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.drugalcdep.2010.07.026
Volume 113
Issue 2-3
Start page 88
End page 95
Total pages 8
Place of publication Clare, Ireland
Publisher Elsevier Ireland
Collection year 2011
Language eng
Formatted abstract
Aims: To conduct a systematic review of mortality among cohort studies of cocaine users. Methods: Three electronic databases were searched (EMBASE, Medline and PsychINFO); other online databases were searched using online libraries and repositories of reports and literature in the drug and alcohol field, with requested contributions from trained librarians and experts. Searches and extraction were undertaken using protocols and cross-checking of decisions by two authors. Additional data were requested from study investigators where studies did not report relevant data. Results: 1911 articles and 2 reports were identified from searches, with data from another four studies located from review articles. Seven cohorts of " problem" or dependent cocaine users reported data that permitted mortality rates to be estimated. Crude mortality rates ranged from 0.53 (95% CI: 0.10-1.58) to 6.16 (95% CI: 5.21-7.11) per 100PY. Standardised mortality ratios (SMRs) reported in four studies suggested that mortality was four to eight times higher among cocaine users than age and sex peers in the general population. Conclusions: There are limited data on the extent of elevated mortality among problematic or dependent cocaine users and it is unclear how generalisable the results of these studies may be to other populations of problematic cocaine users. Greater attention to both the method of recruitment, and the characteristics of cocaine users, would enhance our understanding of the mortality risks of problematic cocaine use.
© 2010 Elsevier Ireland Ltd.
Keyword Cocaine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 15 September 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
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Citation counts: TR Web of Science Citation Count  Cited 55 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 18 Feb 2011, 10:51:37 EST by Caroline Irle on behalf of UQ Centre for Clinical Research