Developmental vitamin D (DVD) deficiency alters pup retrieval but not isolation-induced pup ultrasonic vocalizations in the rat

Burne, Thomas H.J., O'Loan, Jonathan, Splatt, Karisha, Alexander, Suzanne, McGrath, John J. and Eyles, Darryl (2011) Developmental vitamin D (DVD) deficiency alters pup retrieval but not isolation-induced pup ultrasonic vocalizations in the rat. Physiology and Behavior, 102 2: 201-204. doi:10.1016/j.physbeh.2010.11.006


Author Burne, Thomas H.J.
O'Loan, Jonathan
Splatt, Karisha
Alexander, Suzanne
McGrath, John J.
Eyles, Darryl
Title Developmental vitamin D (DVD) deficiency alters pup retrieval but not isolation-induced pup ultrasonic vocalizations in the rat
Journal name Physiology and Behavior   Check publisher's open access policy
ISSN 0031-9384
1873-507X
Publication date 2011-02-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.physbeh.2010.11.006
Volume 102
Issue 2
Start page 201
End page 204
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2011
Language eng
Formatted abstract
Evidence from animal experiments now demonstrates that prenatal vitamin D levels influence brain development. The aims of this study were to examine isolation-induced pup ultrasonic vocalizations and maternal-infant interactions using a pup-retrieval test in developmental vitamin D (DVD) deficient and control rats. Sprague-Dawley rats were fed a vitamin D deficient diet or control diet six weeks prior to mating until birth and housed under UVB-free lighting conditions. In two separate experiments we recorded ultrasonic vocalizations at 46KHz in isolated pups and we performed a pup-retrieval test on the day of birth. There was no significant effect of maternal diet on the calling rate of isolation-induced ultrasonic vocalizations by pups. We found that DVD-deficient dams retrieved their pups sooner than control dams and engaged in more pup directed activities (sniffing and carrying pups) and had a longer latency for self-grooming and rearing than control dams. We also assessed vitamin D related measures from a terminal blood sample immediately after the pup-retrieval test and found that DVD-deficient dams and pups had significantly lower levels of 25 OH D3, 1,25 (OH)2D3 and phosphate, elevated levels of parathyroid hormone (PTH) but there was no significant effect of maternal diet on calcium levels. We speculate that the altered maternal-pup interactions identified in the DVD model may impact on early periods of brain development and behaviour. © 2010 Elsevier Inc.
Keyword Maternal behaviour
Development
Sprague-Dawley rats
Ultrasonic vocalization
Vitamin D
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 6 November 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
ERA 2012 Admin Only
 
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Created: Fri, 18 Feb 2011, 01:38:30 EST by Debra McMurtrie on behalf of Queensland Brain Institute