Analgesic drug dosing requirements to produce satisfactory pain relief with tolerable side-effects are subject to considerable interindividual variability—even in patients with pain of an apparently similar type and intensity. Contributing factors include those of genetic and environmental origin as well as their interaction. Environmental factors include patient age, sex, status of liver and kidney function, lifestyle variables such as smoking and alcohol consumption, disease comorbidities, and concurrent medications. Genetic factors include those related to the regulation of analgesic drug pharmacodynamics and pharmacokinetics.
The Pain: Clinical Updates (P:CU) newsletter is designed to provide clinicians with accurate and timely information about pain therapy. Each issue of this copyrighted IASP publication covers one or two topics of wide medical interest not only to our members, but also for practitioners in a number of specialties. In addition, patients and their families may find many of these articles informative and useful.