Reduced melanoma after regular sunscreen use: Randomized trial follow-up

Green, Adèle C., Williams, Gail M., Logan, Valerie and Strutton, Geoffrey M. (2011) Reduced melanoma after regular sunscreen use: Randomized trial follow-up. Journal of Clinical Oncology, 29 3: 257-263. doi:10.1200/JCO.2010.28.7078


Author Green, Adèle C.
Williams, Gail M.
Logan, Valerie
Strutton, Geoffrey M.
Title Reduced melanoma after regular sunscreen use: Randomized trial follow-up
Journal name Journal of Clinical Oncology   Check publisher's open access policy
ISSN 0732-183X
1527-7755
Publication date 2011-01-20
Year available 2010
Sub-type Article (original research)
DOI 10.1200/JCO.2010.28.7078
Open Access Status
Volume 29
Issue 3
Start page 257
End page 263
Total pages 7
Editor Daniel G. Haller
Ken G. Kornfield
Place of publication Alexandria, VA, U.S.A.
Publisher American Society of Clinical Oncology
Collection year 2011
Language eng
Formatted abstract
Purpose Regular sunscreen use prevents cutaneous squamous cell carcinoma long term, but the effect on melanoma is highly controversial. We evaluated whether long-term application of sunscreen decreases risk of cutaneous melanoma.

Participants and Methods In 1992, 1,621 randomly selected residents of Nambour, a township in Queensland, Australia, age 25 to 75 years, were randomly assigned to daily or discretionary sunscreen application to head and arms in combination with 30 mg beta carotene or placebo supplements until 1996. Participants were observed until 2006 with questionnaires and/or through pathology laboratories and the cancer registry to ascertain primary melanoma occurrence.

Results Ten years after trial cessation, 11 new primary melanomas had been identified in the daily sunscreen group, and 22 had been identified in the discretionary group, which represented a reduction of the observed rate in those randomly assigned to daily sunscreen use (hazard ratio [HR], 0.50; 95% CI, 0.24 to 1.02; P = .051). The reduction in invasive melanomas was substantial (n = 3 in active v 11 in control group; HR, 0.27; 95% CI, 0.08 to 0.97) compared with that for preinvasive melanomas (HR, 0.73; 95% CI, 0.29 to 1.81).

Conclusion Melanoma may be preventable by regular sunscreen use in adults.
© 2010 by American Society of Clinical Oncology
Keyword Skin-cancer prevention
Broad-spectrum sunscreen
Beta-carotene supplementation
Malignant-melanoma
P53 mutations
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print December 6, 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Public Health Publications
UQ Diamantina Institute Publications
 
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Created: Sun, 13 Feb 2011, 00:02:06 EST