Capillary CAA defines a subtype of Alzheimer's disease while pericapillary A beta is a type of early A beta deposition

Attems, J., Ghebremedhin, E., Papassotiropoulos, A., Saido, T. C., Griffin, W. S. T., Mrak, R. E., Koelsch, H., Del Tredici, K., Yamaguchi, H. and Thal, D. R. (2011). Capillary CAA defines a subtype of Alzheimer's disease while pericapillary A beta is a type of early A beta deposition. In: Proceedings of the 112th Meeting of the British Neuropathological Society. BNS 2011: 112th Meeting of the British Neuropathological Society, London, United Kingdom, (9-9). 5-7 January 2011. doi:10.1111/j.1365-2990.2010.01143.x


Author Attems, J.
Ghebremedhin, E.
Papassotiropoulos, A.
Saido, T. C.
Griffin, W. S. T.
Mrak, R. E.
Koelsch, H.
Del Tredici, K.
Yamaguchi, H.
Thal, D. R.
Title of paper Capillary CAA defines a subtype of Alzheimer's disease while pericapillary A beta is a type of early A beta deposition
Formatted title
Capillary CAA defines a subtype of Alzheimer's disease while pericapillary Aß is a type of early Aß deposition
Conference name BNS 2011: 112th Meeting of the British Neuropathological Society
Conference location London, United Kingdom
Conference dates 5-7 January 2011
Proceedings title Proceedings of the 112th Meeting of the British Neuropathological Society   Check publisher's open access policy
Journal name Neuropathology and Applied Neurobiology   Check publisher's open access policy
Place of Publication Oxford, U.K.
Publisher Wiley-Blackwell Publishing
Publication Year 2011
Sub-type Published abstract
DOI 10.1111/j.1365-2990.2010.01143.x
ISSN 0305-1846
1365-2990
Volume 37
Issue Supp. s1
Start page 9
End page 9
Total pages 1
Collection year 2012
Language eng
Formatted Abstract/Summary
Introduction: Cerebral amyloid angiopathy (CAA) is characterized by amyloid-β protein (Aβ) depositions in blood vessel walls and is frequent in Alzheimer’s disease (AD). At the capillary level Aβ can be present in capillary walls as capillary cerebral amyloid angiopathy (capCAA), which is associated with the apolipoprotein E ε4-allele (APOEε4), and along the pericapillary glia limitans (pericapillary Aβ). The presence of capCAA characterizes CAA type 1 in which additional CAA in arteries may be present whereas CAA type 2 is defined by the absence of capCAA. Pericapillary Aβ, on the other hand, is a constant finding in AD. The aim of our study was to identify further differences between CAA type 1 and 2 with respect to AD pathology, and to study the relationship between capCAA and pericapillary Aβ.

Material and methods: In 380 non-selected autopsy cases (71 AD, 50 demented controls, 259 non-demented controls) we investigated distinguishing neuropathological features, alterations in perivascular protein expression and genotype-specific associations. In a subset of 58 cases we additionally assessed pericapillary Aβ.

Results: AD cases with capCAA displayed more widely distributed Aβ-plaque deposits whereas the severity of CAA in arteries did not differ. AD cases with capCAA cases were significantly associated with APOEε4, and with reduced expression of perivascular excitatory amino acid transporter 2 (EAAT-2/GLT-1) in cortical astrocytes. AD cases without capCAA were associated with the T-allele of the α2macroglobulin receptor/low-density lipoprotein receptor-related protein-1 (LRP-1) C766T polymorphism. No significant correlation was found between the presence of capCAA and pericapillary Aβ. The latter did not exhibit N-terminal Aβ-epitopes indicating that pericapAβ predominately consists of so-called ‘N-terminal truncated’ Aβ that is seen in early Aβ deposits.

Conclusions: Our results point towards a specific capCAArelated and APOEε4-associated subtype of AD while pericapillary Aβ may represent early Aβ accumulation.
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication date: January 2011. Published under "Oral Abstracts" as Abstract #O04.

Document type: Conference Paper
Collections: Non HERDC
School of Biomedical Sciences Publications
 
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Created: Sun, 13 Feb 2011, 00:00:40 EST