Survey of the year 2009: applications of isothermal titration calorimetry

Falconer, Robert J. and Collins, Brett M. (2011) Survey of the year 2009: applications of isothermal titration calorimetry. Journal of Molecular Recognition, 24 1: 1-16. doi:10.1002/jmr.1073

Author Falconer, Robert J.
Collins, Brett M.
Title Survey of the year 2009: applications of isothermal titration calorimetry
Journal name Journal of Molecular Recognition   Check publisher's open access policy
ISSN 0952-3499
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1002/jmr.1073
Volume 24
Issue 1
Start page 1
End page 16
Total pages 16
Place of publication West Sussex , United Kingdom
Publisher John Wiley & Sons
Collection year 2011
Language eng
Formatted abstract
Isothermal titration calorimetry (ITC) is now an established and invaluable method for determining the thermodynamic constants, association constant and stoichiometry of molecular interactions in aqueous solutions. The technique has become widely used by biochemists to study protein interaction with other proteins, small molecules, metal ions, lipids, nucleic acids and carbohydrates; and nucleic acid interaction with small molecules. The drug discovery industry has utilized this approach to measure protein (or nucleic acid) interaction with drug candidates. ITC has been used to screen candidates, guide the design of potential drugs and validate the modelling used in structure-based drug design. Emerging disciplines including nanotechnology and drug delivery could benefit greatly from ITC in enhancing their understanding and control of nano-particle assembly, and drug binding and controlled release.
Keyword Calorimetry
Enzyme kinetics
Free energy
Heat capacity
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 14 December 2010.

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Created: Fri, 11 Feb 2011, 10:22:54 EST by Dr Robert Falconer on behalf of Aust Institute for Bioengineering & Nanotechnology