Spider-venom peptides as therapeutics

Seaz, Natalie J., Senff, Sebastian, Jensen, Jonas E., Er, Sing Yan, Herzig, Volker, Rash, Lachlan D. and King, Glenn F. (2010) Spider-venom peptides as therapeutics. Toxins, 2 12: 2851-2871. doi:10.3390/toxins2122851

Author Seaz, Natalie J.
Senff, Sebastian
Jensen, Jonas E.
Er, Sing Yan
Herzig, Volker
Rash, Lachlan D.
King, Glenn F.
Title Spider-venom peptides as therapeutics
Journal name Toxins   Check publisher's open access policy
ISSN 2072-6651
Publication date 2010-12-20
Sub-type Article (original research)
DOI 10.3390/toxins2122851
Open Access Status DOI
Volume 2
Issue 12
Start page 2851
End page 2871
Total pages 21
Place of publication Switzerland
Publisher Molecular Diversity Preservation International (M D P I) AG.
Collection year 2011
Language eng
Formatted abstract
Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapid subjugation of prey. Most spider venoms are dominated by disulfide-rich peptides that typically have high affinity and specificity for particular subtypes of ion channels and receptors. Spider venoms are conservatively predicted to contain more than 10 million bioactive peptides, making them a valuable resource for drug discovery. Here we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against a wide range of pathophysiological conditions including cardiovascular disorders, chronic pain, inflammation, and erectile dysfunction
Keyword Spider venom
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received: 16 November 2010; in revised form: 17 December 2010 / Accepted: 17 December 2010 / Published: 20 December 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 81 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 10 Feb 2011, 18:19:25 EST by Dr Lachlan Rash on behalf of Institute for Molecular Bioscience