Hyperinsulinaemia causes laminitis

de Laat, Melody A., McGowan, C. M., Sillence, M. N. and Pollitt, C. C. (2009). Hyperinsulinaemia causes laminitis. In: John Chopin, Equine Chapter Conference Program and Proceedings. Australian College of Veterinary Scientist 2009 Annual Conference Science Week, Gold Coast , QLD, Australia, (49-51). 2-4 July 2009.

Author de Laat, Melody A.
McGowan, C. M.
Sillence, M. N.
Pollitt, C. C.
Title of paper Hyperinsulinaemia causes laminitis
Conference name Australian College of Veterinary Scientist 2009 Annual Conference Science Week
Conference location Gold Coast , QLD, Australia
Conference dates 2-4 July 2009
Convener Australian College of Veterinary Scientists
Proceedings title Equine Chapter Conference Program and Proceedings
Publication Year 2009
Sub-type Published abstract
Editor John Chopin
Start page 49
End page 51
Total pages 3
Language eng
Formatted Abstract/Summary
Introduction: Laminitis is an ancient problem with a diverse range of inciting causes. Improvements in pasture management and an increased longevity of horses (Paradis 2002) has led to an increase in laminitis occurring secondary to pasture-associated and endocrine causes (USDA 2000), necessitating research in this area. Insulin resistance (IR), manifest as hyperinsulinaemia (Frank 2006; McGowan, Frost, Pfeiffer et al. 2004), is a common feature of endocrinopathic laminitis. Recent research by Asplin and associates has described a new model for inducing laminitis experimentally in clinically normal ponies using a prolonged-euglycaemic hyperinsulinaemic clamp (p-EHC) technique (Asplin, Sillence, Pollitt et al. 2007). This discovery has provided a new focus for research into the mechanisms involved in the pathogenesis of insulin-induced laminitis. To further expand this research it was necessary to determine if hyperinsulinaemia would have a laminitogenic effect in horses as they are less prone to IR than ponies (Jeffcott, Field, McLean et al. 1986).

Conclusions and clinical relevance: Healthy Standardbred horses subjected to prolonged hyperinsulinaemia develop laminitis within 48 hours, demonstrating that laminitis in horses can be triggered by insulin. Further application of this research model will allow more accurate quantification of the minimum period and degree of hyperinsulinaemia required to induce laminitis and the potential for individual variation amongst animals. Consistently elevated HWST may prove to be an effective diagnostic tool in the prodromal phase of insulin-induced laminitis. Insulin resistance and the associated hyperinsulinaemia place horses and ponies at risk of developing laminitis. By using this research model to study endocrinopathic laminitis we hope to advance our understanding of the disease and improve current prevention and therapeutic strategies
Subjects 0707 Veterinary Sciences
Keyword Laminitis
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: School of Veterinary Science Publications
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Created: Thu, 10 Feb 2011, 15:40:35 EST by Miss Melody De Laat on behalf of School of Veterinary Science