The transgenic mouse in studies of mammalian sexual differentiation.

Whitworth, Deanne J. and Behringer, Richard R. (2001). The transgenic mouse in studies of mammalian sexual differentiation.. In Martin M. Matzuk, Chester W. Brown, T. Rajendra Kumar and P. Michael Conn (Ed.), Transgenics in Endocrinology (pp. 19-39) Totowa, NJ, U.S.A.: Humana Press.

Author Whitworth, Deanne J.
Behringer, Richard R.
Title of chapter The transgenic mouse in studies of mammalian sexual differentiation.
Title of book Transgenics in Endocrinology
Place of Publication Totowa, NJ, U.S.A.
Publisher Humana Press
Publication Year 2001
Sub-type Research book chapter (original research)
Series Contemporary Endocrinology
ISBN 9780896037649; 0896037649; 9781592591022; 1592591027; 0196-8653
Editor Martin M. Matzuk
Chester W. Brown
T. Rajendra Kumar
P. Michael Conn
Chapter number 2
Start page 19
End page 39
Total pages 22
Total chapters 20
Language eng
Formatted Abstract/Summary
Throughout history, the subject of sex has held an inherent fascination. The musings of Aristotle on the role of “an infinitesimally minute but essential organ” in determining whether “the animal will in one case turn to male (or) in the other to female” (Aristotle, Historia Animalium), offer an early insight into what has become one of the tenets in our understanding of sexual differentiation in mammals: that the sex of the gonad determines the sexual development of the individual.

Sex determination in mammals is a remarkable process that has its origin in an indifferent gonadal primordium, common to both sexes, which has the ability to differentiate into either a testis or an ovary. In the presence of a Y chromosome, the indifferent gonad develops as a testis; in the absence of a Y chromosome, and regardless of the number of X chromosomes present, the indifferent gonad develops as an ovary. Remarkably, until fairly recently, this was about all we knew with respect to the genetic events involved in testicular differentiation. With the discovery in 1990 of SRY (sex-determining-region, Y chromosome gene), the testis-determining gene on the Y chromosome, the field seemed set for the systematic isolation of other genes functioning in the testicular differentiation pathway. Eleven years have now passed since the discovery of SRY, and the pathway from indifferent gonad to testis appears ever more complex. Our understanding of the ovarian differentiation process is even more limited.

The use of transgenic mice has contributed enormously to our understanding of the mammalian sex determination and sexual differentiation pathways, and hence is the focus of this chapter. While there is no denying the wealth of information gleaned from mouse models, it is also our belief that much can be learned from comparative studies of other mammalian systems. This chapter concludes with a brief introduction to the efforts that are underway to generate the first transgenic marsupial.
© Humana Press Inc., Totowa, NJ
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
Collection: School of Veterinary Science Publications
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Wed, 09 Feb 2011, 13:44:19 EST by Dr Deanne Whitworth on behalf of School of Veterinary Science