High specificity of Müllerian-inhibiting substance signaling in vivo

Mishina, Y., Whitworth, D. J., Racine, C. and Behringer, R. R.. (1999) High specificity of Müllerian-inhibiting substance signaling in vivo. Endocrinology, 140 5: 2084-2088. doi:10.1210/en.140.5.2084

Author Mishina, Y.
Whitworth, D. J.
Racine, C.
Behringer, R. R..
Title High specificity of Müllerian-inhibiting substance signaling in vivo
Journal name Endocrinology   Check publisher's open access policy
ISSN 0013-7227
Publication date 1999-05
Sub-type Article (original research)
DOI 10.1210/en.140.5.2084
Volume 140
Issue 5
Start page 2084
End page 2088
Total pages 5
Place of publication Chevy Chase, MD, United States
Publisher The Endocrine Society
Language eng
Abstract Female transgenic mice that ectopically express high levels of human Mullerian-inhibiting substance (hMIS) under the control of the mouse metallothionein (MT) promoter lack a uterus, oviducts, and ovaries. The loss of the uterus and oviducts is consistent with the known activities for MIS. However, it is not clear if the loss of the ovaries in these transgenic females is caused by interactions of MIS with its normal receptor signaling pathway or by abnormal interactions with other transforming growth factor-β (TGF-β) super family receptor signaling pathways. To address this question, female mice carrying the MT-hMIS transgene that were also homozygous for a targeted deletion of the MIS type II receptor gene were generated. Although these females had high levels of circulating hMIS, they had normal reproductive tracts and ovaries with germ cells. In addition, these females were able to become pregnant and gave birth to pups. These findings demonstrate that all of the abnormalities of the reproductive system that are found in female transgenic mice that ectopically express high levels of hMIS are caused by signaling through the MIS type II receptor. These in vivo data demonstrate a high specificity for MIS and its receptor.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
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Created: Wed, 09 Feb 2011, 11:14:59 EST by Dr Deanne Whitworth on behalf of School of Veterinary Science