Some effects of chronic mercuric chloride intoxication on renal function in a horse

Roberts, M. C., Seawright, A. A., Ng, J. C. and Norman, P. D. (1982) Some effects of chronic mercuric chloride intoxication on renal function in a horse. Veterinary and Human Toxicology, 24 6: 415-420.

Author Roberts, M. C.
Seawright, A. A.
Ng, J. C.
Norman, P. D.
Title Some effects of chronic mercuric chloride intoxication on renal function in a horse
Journal name Veterinary and Human Toxicology   Check publisher's open access policy
ISSN 0145-6296
Publication date 1982
Sub-type Article (original research)
Volume 24
Issue 6
Start page 415
End page 420
Total pages 6
Place of publication Manhattan, KS, United States
Publisher Comparative Toxicology Laboratories
Language eng
Abstract Chronic mercuric chloride intoxication in an aged horse given 0.8 mg Hg/kg/day for 14 weeks was manifest by signs of progressive respiratory difficulty and renal disease. The effects were not self-limiting after mercury was withdrawn, and the animal was destroyed six weeks later. Renal function changes included heavy glycosuria, modest proteinuria, phosphaturia, reduced urine osmolality, gradually increasing urine production, reduced glomerular filtration rate, and terminally, azotemia. The condition bore similarities to the Fanconi syndrome in man. Urinary gamma-glutamyl transpeptidase, alkaline phosphatase and amino-aspartate transferase activities were inconsistent indicators of tubular damage in random samples at this dose rate. The pathologic response was characterized by extensive granulomatous infiltration throughout the lungs, in particular, and to a lesser extent in the kidneys, liver and bone marrow. The renal changes included this marked interstitial reaction and proximal tubular degeneration. Mercury levels were negligible in the lungs and highest in the renal cortex. The granulomatous reaction was not encountered in previous mercury toxicity studies in horses and may indicate an individual sensitivity to the agent.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
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Created: Wed, 09 Feb 2011, 10:52:44 EST