Uncovering gene regulatory networks during mouse fetal germ cell development

Rolland, Antoine, Lehmann, Kim P., Johnson, Kamin J., Gaido, Kevin W. and Koopman, Peter A. (2011) Uncovering gene regulatory networks during mouse fetal germ cell development. Biology of Reproduction, 84 4: 790-800. doi:10.1095/biolreprod.110.088443


Author Rolland, Antoine
Lehmann, Kim P.
Johnson, Kamin J.
Gaido, Kevin W.
Koopman, Peter A.
Title Uncovering gene regulatory networks during mouse fetal germ cell development
Journal name Biology of Reproduction   Check publisher's open access policy
ISSN 0006-3363
Publication date 2011-04-01
Year available 2010
Sub-type Article (original research)
DOI 10.1095/biolreprod.110.088443
Volume 84
Issue 4
Start page 790
End page 800
Total pages 11
Place of publication Madison, WI, U.S.A.
Publisher Society for the Study of Reproduction
Collection year 2011
Language eng
Formatted abstract
The commitment of germ cells to either oogenesis or spermatogenesis occurs during fetal  gonad development: germ cells either enter meiosis or mitotic arrest, depending on whether they reside within an ovary or a testis, respectively. Despite the critical importance of this step for sexual reproduction, gene networks underlying germ cell development have remained only partially understood. Taking advantage of the Wv mouse model, in which gonads lack germ cells, we conducted a microarray study to identify genes expressed in fetal germ cells. In addition to distinguishing genes expressed by germ cells from those expressed by somatic cells within the developing gonads, we were able to highlight specific groups of genes expressed in female or male germ cells only. Our results provide an important resource for deciphering the molecular pathways driving proper germ cell development and sex determination, and will improve our understanding of the etiology of human germ cell tumours that arise from dysregulation of germ cell differentiation.
Keyword Mouse
Germ cell
Fetal gonad
Meiosis
Pluripotency
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 8 December, 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 08 Feb 2011, 10:59:28 EST by Susan Allen on behalf of Institute for Molecular Bioscience