Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy

Bhat, Purnima, Mattarollo, Stephen R., Gosmann, Christina, Frazer, Ian H. and Leggatt, Graham R. (2011) Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy. Immunological Reviews, 239 1: 85-98. doi:10.1111/j.1600-065X.2010.00966.x

Author Bhat, Purnima
Mattarollo, Stephen R.
Gosmann, Christina
Frazer, Ian H.
Leggatt, Graham R.
Title Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy
Journal name Immunological Reviews   Check publisher's open access policy
ISSN 0105-2896
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1111/j.1600-065X.2010.00966.x
Volume 239
Issue 1
Start page 85
End page 98
Total pages 14
Place of publication Malden, MA, U.S.A.
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract
The recent development of vaccines prophylactic against human papillomavirus (HPV) infection has the potential to reduce the incidence of cervical cancer globally by up to 70% over the next 40 years, if universal immunization is adopted. As these prophylactic vaccines do not alter the natural history of established HPV infection, immunotherapies to treat persistent HPV infection and associated precancers would be of benefit to assist with cervical cancer control. Efforts to develop immuno-therapeutic vaccines have been hampered by the relative non-immunogenicity of HPV infection, by immunoregulatory processes in skin, and by subversion of immune response induction and immune effector functions by papillomavirus proteins. This review describes HPV-specific immune responses induced by viral proteins, their regulation by host and viral factors, and highlights some conclusions from our own recent research.
Keyword Cervical cancer
NKT cells
Papillomavirus infection
Human-papillomavirus type-16
Cervical intraepithelial neoplasia
Squamous-cell carcinoma
Killer T-cells
Nonobese diabetic mice
IFN-gamma production
Experimental autoimmune encephalomyelitis
Invariant NKT cells
Class-I molecules
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 28 DEC 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 40 times in Scopus Article | Citations
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Created: Sun, 06 Feb 2011, 00:08:59 EST