Inhibition dominates the early phase of up-states in the basolateral amygdala

Windels, Francois, Crane, James W. and Sah, Pankaj (2010) Inhibition dominates the early phase of up-states in the basolateral amygdala. Journal of Neurophysiology, 104 6: 3433-3438. doi:10.1152/jn.00531.2010

Author Windels, Francois
Crane, James W.
Sah, Pankaj
Title Inhibition dominates the early phase of up-states in the basolateral amygdala
Journal name Journal of Neurophysiology   Check publisher's open access policy
ISSN 0022-3077
Publication date 2010-12
Sub-type Article (original research)
DOI 10.1152/jn.00531.2010
Volume 104
Issue 6
Start page 3433
End page 3438
Total pages 6
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Collection year 2011
Language eng
Abstract Slow oscillations (<1 Hz) in neural activity occur during sleep and quiet wakefulness in both animals and humans. Single-cell recordings in cortical neurons have shown that these oscillations are driven by a combination of excitatory and inhibitory synaptic inputs. During up-states, although the ratio between them varies between cells, excitation and inhibition follow similar time courses. Neurons in the basolateral amygdala (BLA) also show slow oscillations between the resting membrane potential (down-state) and depolarized potentials (upstates). Delivery of footshock during the down-state fully reproduces up-states in these cells. Here we report that up-states in BLA principal neurons up-states begin with an excitatory drive that is rapidly (within ̃50 ms) overwhelmed by inhibitory input. This excess of inhibitory drive is short lasting (300-400 ms), after which up-states are maintained by a tight balance between excitation and inhibition. This initial large inhibitory input restricts action potential generation and reduces the firing frequency of these cells. These results indicate that, in contrast to cortical neurons, up-states in BLA neurons show an initial period of strong cortically driven feed-forward inhibition. For the remainder of the up-state, feedback inhibition then acts to balance excitatory input. Copyright © 2010 The American Physiological Society.
Keyword Less than 1hz oscillation
Firing patterns
Fear memory
Neuronal oscillations
Lateral amygdala
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 06 Feb 2011, 00:06:15 EST