Effect of the dose volume of perfluorocarbon when starting partial liquid ventilation

Davies, MW, Dunster, KR, Wilson, K and Colditz, PB (2010) Effect of the dose volume of perfluorocarbon when starting partial liquid ventilation. Journal of Paediatrics and Child Health, 46 12: 714-722. doi:10.1111/j.1440-1754.2010.01828.x

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Author Davies, MW
Dunster, KR
Wilson, K
Colditz, PB
Title Effect of the dose volume of perfluorocarbon when starting partial liquid ventilation
Journal name Journal of Paediatrics and Child Health   Check publisher's open access policy
ISSN 1034-4810
1440-1754
Publication date 2010-12
Sub-type Article (original research)
DOI 10.1111/j.1440-1754.2010.01828.x
Volume 46
Issue 12
Start page 714
End page 722
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2011
Language eng
Formatted abstract
Objective: Very preterm neonates are prone to brain injury if cerebral blood flow fluctuates. Partial liquid ventilation (PLV) may benefit any lung disease but giving 30 mL/kg of perfluorocarbon when starting PLV increases cortical cerebral blood flow velocity. We aimed to determine if varying the initial dose of perfluorocarbon alters the effect on cerebral blood flow velocity when starting PLV.
Methods: In this randomised, controlled trial with historical comparison 24 preterm lambs received one of three loading doses of intratracheal perfluorocarbon liquid over 20 min when starting PLV: 20, 30 or 40 mL/kg. Data on respiratory mechanics, haemodynamics and cerebral blood flow velocity, measured with laser Doppler, were collected continuously for 30 min from the start of dosing.
Results: Cortical cerebral blood flow velocity increased over time in all three groups (two-way ANOVA, P= 0.007). There was no difference between groups (two-way ANOVA, P= 0.26). There was no difference between groups in cortical cerebral blood flow velocity variability (P= 0.68), blood pressure (P= 0.96) or heart rate (P= 0.46). The was no statistically significant difference in PaCO2 between groups measured at baseline and at 30 min after starting PLV (P= 0.51).
Conclusions: Cortical cerebral blood flow velocity and its variability are not affected by varying doses of tracheal perfluorocarbon (20, 30 or 40 mL/kg) at the start of PLV in preterm lambs. © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
Keyword Cerebral blood flow
Dose-response relationship
Drug
Fluorocarbon
Infant
Preterm
Partial liquid ventilation
Respiratory function test
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 06 Feb 2011, 00:05:59 EST