Drug structure-transport relationships

Roberts, MS (2010) Drug structure-transport relationships. Journal of Pharmacokinetics And Pharmacodynamics, 37 6: 541-573. doi:10.1007/s10928-010-9174-0


Author Roberts, MS
Title Drug structure-transport relationships
Journal name Journal of Pharmacokinetics And Pharmacodynamics   Check publisher's open access policy
ISSN 1567-567X
1573-8744
Publication date 2010-12-01
Sub-type Article (original research)
DOI 10.1007/s10928-010-9174-0
Volume 37
Issue 6
Start page 541
End page 573
Total pages 34
Place of publication New York, United States
Publisher Springer New York
Collection year 2011
Language eng
Abstract Malcolm Rowland has greatly facilitated an understanding of drug structure-pharmacokinetic relationships using a physiological perspective. His view points, covering a wide range of activities, have impacted on my own work and on my appreciation and understanding of our science. This overview summarises some of our parallel activities, beginning with Malcolm's work on the pH control of amphetamine excretion, his work on the disposition of aspirin and on the application of clearance concepts in describing the disposition of lidocaine. Malcolm also spent a considerable amount of time developing principles that define solute structure and transport/pharmacokinetic relationships using in situ organ studies, which he then extended to involve the whole body. Together, we developed a physiological approach to studying hepatic clearance, introducing the convection-dispersion model in which there was a spread in blood transit times through the liver accompanied by permeation into hepatocytes and removal by metabolism or excretion into the bile. With a range of colleagues, we then further developed the model and applied it to various organs in the body. One of Malcolm's special interests was in being able to apply this knowledge, together with an understanding of physiological differences in scaling up pharmacokinetics from animals to man. The description of his many other activities, such as the development of clearance concepts, application of pharmacokinetics to the clinical situation and using pharmacokinetics to develop new compounds and delivery systems, has been left to others. © The Author(s) 2010.
Keyword Malcolm Rowland
Physiological pharmacokinetics
Structure-transport relationships
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue: Tribute to Malcolm Rowland

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 06 Feb 2011, 10:05:45 EST