Role of the primary motor and sensory cortex in precision grasping: a transcranial magnetic stimulation study

Schabrun, S. M., Ridding, M. C. and Miles, T. S, (2008) Role of the primary motor and sensory cortex in precision grasping: a transcranial magnetic stimulation study. European Journal of Neuroscience, 27 3: 750-756. doi:10.1111/j.1460-9568.2008.06039.x


Author Schabrun, S. M.
Ridding, M. C.
Miles, T. S,
Title Role of the primary motor and sensory cortex in precision grasping: a transcranial magnetic stimulation study
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 0953-816X
1460-9568
Publication date 2008-02
Sub-type Article (original research)
DOI 10.1111/j.1460-9568.2008.06039.x
Volume 27
Issue 3
Start page 750
End page 756
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract Human precision grip requires precise scaling of the grip force to match the weight and frictional conditions of the object. The ability to produce an accurately scaled grip force prior to lifting an object is thought to be the result of an internal feedforward model. However, relatively little is known about the roles of various brain regions in the control of such precision grip-lift synergies. Here we investigate the role of the primary motor (M1) and sensory (S1) cortices during a grip-lift task using inhibitory transcranial magnetic theta-burst stimulation (TBS). Fifteen healthy individuals received 40 s of either (i) M1 TBS, (ii) S1 TBS or (iii) sham stimulation. Following a 5-min rest, subjects lifted a manipulandum five times using a precision grip or completed a simple reaction time task. Following S1 stimulation, the duration of the pre-load phase was significantly longer than following sham stimulation. Following M1 stimulation, the temporal relationship between changes in grip and load force was altered, with changes in grip force coming to lag behind changes in load force. This result contrasts with that seen in the sham condition where changes in grip force preceded changes in load force. No significant difference was observed in the simple reaction task following either M1 or S1 stimulation. These results further quantify the contribution of the M1 to anticipatory grip-force scaling. In addition, they provide the first evidence for the contribution of S1 to object manipulation, suggesting that sensory information is not necessary for optimal functioning of anticipatory control.
Keyword grip-lift task
internal model
sensorimotor control
theta-burst stimulation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Health and Rehabilitation Sciences Publications
 
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Created: Fri, 04 Feb 2011, 14:56:35 EST