Age-related changes in heart function by serial echocardiography in women aged 40-80 years

Scalia, Gregory M., Khoo, Soo Keat, O'Neill, Sheila and LAW Study Group (2010) Age-related changes in heart function by serial echocardiography in women aged 40-80 years. Journal of Women's Health, 19 9: 1741-1745. doi:10.1089/jwh.2009.1752


Author Scalia, Gregory M.
Khoo, Soo Keat
O'Neill, Sheila
LAW Study Group
Title Age-related changes in heart function by serial echocardiography in women aged 40-80 years
Journal name Journal of Women's Health   Check publisher's open access policy
ISSN 1540-9996
Publication date 2010-09-01
Year available 2010
Sub-type Article (original research)
DOI 10.1089/jwh.2009.1752
Volume 19
Issue 9
Start page 1741
End page 1745
Total pages 5
Place of publication Larchmont, NY, U.S.A.
Publisher Mary Ann Liebert, Inc.
Collection year 2011
Language eng
Formatted abstract
Aim:  To determine if a defined set of echocardiographic parameters at entry and exit of a longitudinal study over 5 years showed changes with aging.

Methods:  The cohort consisted of 484 randomly recruited women aged 40-80. They were examined by two echocardiography cardiologists, independent of the medical information for these women.

Results: Across the age decades (40-49, 50-59, 60-69, 70-79 years), body weight and body surface area (BSA) did not vary, and diastolic blood pressure (DBP) was stable; systolic blood pressure (SBP) progressively increased. There was gradual decline in left ventricular (LV) diastolic function, increase in LV muscle mass, and decrease in LV end-diastolic volume (LVEDV). The serial decrease in rate of change over 5 years in ejection fraction (ET) was small but significant across the four age decades.

Conclusions: 
As expected, there were age-related changes in cardiac structure and function over time in women who showed no apparent cardiovascular disease (CVD) at entry to the study. The direction of these serial changes was toward the development of LV stiffness and likelihood of subsequent heart failure. The clinical significance of the decrease in rate of change in EF remains unclear.
© 2010, Mary Ann Liebert, Inc.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Fri, 04 Feb 2011, 14:29:21 EST by Ann Hanson on behalf of Obstetrics & Gynaecology - RBWH