Innate immunity: Cytoplasmic DNA sensing by the AIM2 inflammasome

Schroder, Kate, Muruve, Daniel A. and Tschopp, Jürg (2009) Innate immunity: Cytoplasmic DNA sensing by the AIM2 inflammasome. Current Biology, 19 6: R262-R265. doi:10.1016/j.cub.2009.02.011


Author Schroder, Kate
Muruve, Daniel A.
Tschopp, Jürg
Title Innate immunity: Cytoplasmic DNA sensing by the AIM2 inflammasome
Journal name Current Biology   Check publisher's open access policy
ISSN 0960-9822
1879-0445
Publication date 2009-03-24
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.cub.2009.02.011
Volume 19
Issue 6
Start page R262
End page R265
Total pages 4
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Abstract Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1β in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1β maturation and pyroptotic cell death.reserved.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 64 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 02 Feb 2011, 17:18:28 EST by Dr Kate Schroder on behalf of Institute for Molecular Bioscience