Franklinolidesa A - C from an Australian marine sponge complex: Phosphodiesters strongly enhance polyketide cytotoxicity

Zhang, Hua, Conte, Melissa M. and Capon, Robert J. (2010) Franklinolidesa A - C from an Australian marine sponge complex: Phosphodiesters strongly enhance polyketide cytotoxicity. Angewandte Chemie - International Edition, 49 51: 9904-9906. doi:10.1002/anie.201005883


Author Zhang, Hua
Conte, Melissa M.
Capon, Robert J.
Title Franklinolidesa A - C from an Australian marine sponge complex: Phosphodiesters strongly enhance polyketide cytotoxicity
Journal name Angewandte Chemie - International Edition   Check publisher's open access policy
ISSN 1433-7851
1521-3773
Publication date 2010-12-17
Sub-type Article (original research)
DOI 10.1002/anie.201005883
Volume 49
Issue 51
Start page 9904
End page 9906
Total pages 3
Editor Peter Goelitz
Place of publication Weinheim, Germany
Publisher Wiley-VCH
Collection year 2011
Language eng
Formatted abstract
Rare discovery: Three novel polyketide phosphodiesters, franklinolidesa A-C, were identified as the cytotoxic components from an Australian marine sponge complex. Preliminary structure-activity relationship studies, using in vitro cytotoxicity and cell proliferation assays, demonstrated that the introduction of the phosphodiester moiety significantly improved the cytotoxicity by 30 to >300 fold. Copyright
© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keyword Cytotoxicity
Franklinolides
Natural products
Phosphodiesters
Polyketides
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
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Created: Sun, 30 Jan 2011, 00:07:46 EST